Serology in Children with EM Rash: Sensitivity Lacking

Journal of the Pediatric Infectious Diseases Society (Thompson, A.D., et al) 09.26.2023 published, “Sensitivity of Two-Tiered Lyme Disease Serology in Children with an Erythema Migrans Lesion.” Results of this study showed that sensitivity of serologic detection of Lyme disease was higher in children that presented with multiple erythema migrans (EM) lesions, than those with a single lesion. However, less than 77% of children that developed multiple lesions and less than 39% of children that developed a single lesion tested positive by two tier serology.

This study demonstrated that lack of sensitivity in two-tier testing makes careful physical examination of children critical to early and accurate diagnosis for Lyme disease.

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