Powassan (POW) is caused by a flavivirus. There are two virus types. One virus type is transmitted by the deer tick/blacklegged tick (Ixodes scapularis): lineage 2 POW virus (“deer tick virus”). The other virus type is transmitted by other Ixodes ticks – Ixodes marxi (squirrel tick), and Ixodes cookei (woodchuck tick–found E. of Rockies into New England & Canada): lineage 1 POW virus. The Rocky Mountain Wood tick (Dermacentor andersoni) and Ixodes spinipalpus can also transmit the virus.
Humans are “dead end” hosts (ticks can’t pick up disease from them).
Transmission time can be within minutes of the bite. Incubation period is 1 week to 1 month after a bite.
Symptoms include headache, fever, nausea, vomiting, stiff neck, and sleepiness, breathing distress, confusion, tremors, seizures, paralysis, and possible coma. Encephalitis and meningitis can occur – 10% of encephalitis cases result in death.
Survivors of POW: 50% have permanent neurologic problems – Headaches, muscle wasting, memory problems
Supportive treatment is the only available treatment.
Tests for POW: Serum or CSF to detect virus-specific IgM & neutralizing antibodies
“Powassan could become epidemic like Lyme disease. Because it can be a serious disease causing fatalities and there is no treatment for it, Powassan has the potential to become a greater of a public health threat than Lyme disease.” – Professor Emeritus of Epidemiology at the Yale School of Public Health, Durland Fish, PhD.
Powassan Virus photo: Canad. Med Assn. J. 5-2-64
See: Trever M Koester, BS, Priyanka Timothy, MD, Jennifer K Meece, PhD, Rebecca A Osborn, MPH and Holly M Frost, MD. Suspected Neuro-invasive Powassan Virus Infection in a Pediatric Patient. Clinical Medicine & Research. 2020, vol. 18 no. 2-3 95-98