Potential Biomarkers for Neuro Lyme
Scientific Reports (Gyllemark, P; et al.) published 6.15.23 “Intrathecal Th17-driven inflammation is associated with prolonged post-treatment convalescence for patients with Lyme neuroborreliosis.” In this study, researchers investigated the forces of identified cytokines and chemokines that are responsible for inflammatory response during Lyme neuroborreliosis (LNB) to identify potential biomarkers for this inflammatory activity.
Researchers found that the levels of the cytokines and chemokines in the cerebral spinal fluid (CSF) were significantly higher at baseline in patients with LNB compared with controls in the study. IL-17A remained elevated in these patients with LNB and delayed or prolonged recovery post treatment. Lower levels of CCL20 at baseline and lower levels of IL-17A at 1-month follow-up were significant in patients that exhibited rapid recovery. No other cytokines or chemokines were found to be associated with prolonged recovery, indicating persistent Th17-driven inflammation in the CSF is associated with prolonged recovery. IL-17A and CCL20 were identified as potential biomarkers.