New Understanding of Pathway for Neuro Lyme

Neurological lyme disease

Infection and Immunity (Alanazi, F., et al.) 10.24.2023 electronically published ahead of print, “The Rrp2-RpoN-RpoS pathway plays an important role in the blood-brain barrier transmigration of the Lyme disease pathogen.” In this study, researchers investigated factors that enable the Lyme pathogen to cross the blood-brain barrier (BBB) and invade the central nervous system (CNS).

A central regulatory pathway required for infection in mammals is the Rrp2-RpoN-RpoS pathway. Using a “transwell BBB model” based on human brain-microvascular endothelial cells, investigators demonstrated that the Rrp2-RpoN-RpoS pathway is critical for BBB transmigration of the Lyme spirochete. They also found that OspC, a major surface lipoprotein of the bacteria controlled by the Rrp2-RpoN-RpoS pathway,  contributes significantly to BBB transmigration, and central nervous system infection.


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