Model for Neuro-Lyme: 3D Blood-Brain Barrier-Organoids

IScience, (Adams,Y; et al.) published “3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism,” on December 19, 2022. This is an Open Access publication.

Graphical abstract: Open Access

Summary: 

“Lyme neuroborreliosis (LNB), a tick-borne infection caused by spirochetes within the Borrelia burgdorferi sensu lato (s.l.) complex, is among the most prevalent bacterial central nervous system (CNS) infections in Europe and the US. Here we have screened a panel of low-passage Bburgdorferi s.l. isolates using a novel, human-derived 3D blood-brain barrier (BBB)-organoid model. We show that human-derived BBB-organoids support the entry of Borrelia spirochetes, leading to swelling of the organoids and a loss of their structural integrity. The use of the BBB-organoid model highlights the organotropism between Bburgdorferi s.l. genospecies and their ability to cross the BBB contributing to CNS infection.”


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