Neurological Infections and the Choroid Plexus

Infectious Agents and Alzheimer's DiseaseFluids and Barriers of the CNS, (Thompson, D. et al.) published “The choroid plexus and its role in the pathogenesis of neurological infections” on September 10, 2022. This review article summarizes the current knowledge of the choroid plexus and presents the new understanding of the role the choroid plexus plays as in the pathogenesis of neurological infections.

The choroid plexus is a highly vascularized complex whose primary role is the production and secretion cerebrospinal fluid. Many of the cells of the choroid plexus provide surveillance of the immune system by detecting pathogens and changes in the cytokine environment. The choroid plexus is located within each of the four ventricles of the brain and may play a bigger role in the pathogenesis of diseases that pass to the central nervous system than previously understood.

This review discusses the cellular response of the choroid plexus to many diseases including Zika, COVID, and Lyme. Authors believe that further understanding of the complex role the choroid plexus has in powering these disorders could promote development of novel and effective modes of therapy and targets.  

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