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NIH Funding Post Treatment Lyme Research for 5 Projects
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The National Institutes of Health (NIH) announced in a press release on 7.21.23 that they have awarded approximately $3.2 million dollars in funding for this first year of research focused […]
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This Research/Other Pub section includes peer-reviewed articles on cutting edge research or on existing research to either substantiate it or question its findings. Peer-reviewed articles are those in which a panel of experts in the same fields as the authors reviews the articles prior to publication to ensure scientific quality. This section also includes other publications which are not peer-reviewed.
The LDA is providing the articles in this section for your information. The articles included express the findings and opinions of the authors and are not necessarily those of the the LDA.
The National Institutes of Health (NIH) announced in a press release on 7.21.23 that they have awarded approximately $3.2 million dollars in funding for this first year of research focused […]
The eBioMedicine Journal (Bézay, N., et al.) 07.04.2023, published “Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults.”
This study investigates a Lyme borreliosis vaccine candidate (VLA15) to prevent an infection with pathogenic Borrelia spp which in prevalent in North America. Lyme borreliosis can potentially lead to long-term complications and so developing a vaccine that could prevent such serious effects would be life changing. Trials were performed on a randomized group of eligible healthy adults between 18 and 40 years old. Adverse reactions to the vaccine ranged from mild to moderate (please read the article for more details of adverse reactions). The results of the trials were that the VLA15 vaccine against Lyme borreliosis was safe and immunogenic, meaning it was able to produce an immune response, and “paves the way to further clinical development.”
The Vector-Borne and Zoonotic Diseases Journal (Clark K. L. & Nunez J. V.) 07.10.2023, published “Detection of Bartonella DNA in Yellow Flies, Lone Star Ticks, and a Human Patient with Concurrent Evidence of Borrelia burgdorferi Infection in Northeast Florida, USA.” This study investigates cases of Bartonella species and Borrelia burgdorferi sensu lato (Bbsl) in yellow flies in northeast Florida that led to the discovery of cases of Bartonella and Bbsl in lone star ticks and one human patient.
By sampling the flies, ticks, and one human patient in Florida, who had experienced chronic relapsing and remitting symptoms for over a decade, and detecting Bartonella and Bbsl, this study strengthens the understudy of these vectors in the southern United States, but more studies of these vectors in these hosts are needed.
The Nature Communications Journal (Puthussery J. V., et al.) 07.10.2023, published “Real-Time Environmental Surveillance of SARS-CoV-2 Aerosols.” This study focuses on the use of virus aerosol detection to test the air to detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is spread through droplets in the air, expelled from people when they cough, sneeze, breathe, and speak.
Parasites Vectors (Burtis, J.C., et al.) 7.10.23, published “Comparison of in vitro and in vivo repellency bioassay methods for Ixodes scapularis nymphs.” In vitro bioassay methods are most commonly used for the testing of new potential unregistered active ingredients. This study aimed to compare both in vitro (use of artificial containers) and in vivo (human subject) methods.
Reporting in Current Rheumatoligical Review (Puri, B.K. et al) 6.5.23, has indicated that infection by genus Borrelia may be associated with antinuclear antibodies (ANA) in a a small number of cases, so researchers decided to test the hypothesis that fibromyalgia patients who are ANA positive will show evidence of Borrelia specific T lymphocyte activity more than those who are seronegative. Twenty-seven fibromyalgia patients who fit the American College of Rheumatology diagnostic criteria were used in the study.
The Microorganisms Journal (Shor S. M., et al.) 07.05.2023, published “The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses.”
This study explores the use of bioactive phytochemicals, nutraceuticals, and micronutrients (dietary supplements) that could help with the management of persistent cases of Lyme disease and other tick-borne diseases (Borrelia burgdorferi, Babesia, and Bartonella). Normally, antibiotics are prescribed to treat patients with acute Lyme disease, but there is evidence that using antibiotics “may leave up to 15–35% of people with chronic symptoms and health issues” when used to treat Lyme disease. Recent studies have shown that different dietary supplements can be used on patients with Lyme disease and other tick-borne illnesses to help decrease the long-term use of antibiotics, and therefore possibly decrease the chronic symptoms and health issues that may come along with it.
Microorganisms (Siegel, E.L., et al.) 5.27.23, published “Human-Biting Ixodes scapularis Submissions to a Crowd-Funded Tick Testing Program Correlate with the Incidence of Rare Tick-Borne Disease: A Seven-Year Retrospective Study of Anaplasmosis and Babesiosis in Massachusetts.” The study sought to expand upon prior passive Ixodes scapularis tick testing surveillance measures by including two rare tick-borne diseases, babesiosis and anaplasmosis.
The Antibiotic Journal (Trouillas P. & Franck M.) 06.07.2023, published “Complete Remission in Paralytic Late Tick-Borne Neurological Disease Comprising Mixed Involvement of Borrelia, Babesia, Anaplasma, and Bartonella: Use of Long-Term Treatments with Antibiotics and Antiparasitics in a Series of 10 Cases.”
“This study aimed to demonstrate that severe neurological motor deficits in the context of late tick-borne disease with mixed microorganism involvement are eligible for long-term combined antibiotic/antiparasitic treatments.” Patients that met the inclusion criteria were with treated multiple cycles of different antibiotics and antiparasitics. Before treatments, a group of 10 patients had severe motor deficits including needing wheelchairs and using walking sticks. After treatment, 7 out of the 10 patients showed complete remission. The other 3 patients showed initial remission but later suffered antibiotic/antiparasitic-resistant motor reoccurrences. Another group of 9 patients showed 7 patients in total remission.
The Microbiology Journal (Dumic E., et al.) 06.02.2023, published “Anaplasma phagocytophilum Community-Acquired Pneumonia: Case Report and Literature Review.”
This case report focuses on an immunocompetent patient that presented non-specific symptoms including a fever, cough, and shortness of breath. An X-ray and CT scan showed signs of pneumonia, and the patient was tested for both common and uncommon causes and results came back positive for anaplasmosis. Anaplasma phagocytophilum is a pathogen that can cause community-acquired pneumonia and is most commonly transmitted through a tick bite. The case report covers the importance of looking for the signs of anaplasmosis pneumonia in patients with pneumonia so that the proper treatment can be used in patients.
LDA Doctor Referral System © Terms & Conditions and Guidelines
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About LDA DOCTOR REFERRAL SYSTEM ©
Welcome to the Lyme Disease Association’s LDA Doctor Referral System ©. LDA made updates and enhancements to its prior system and has launched a new site to provide patients with information about doctors, other practitioners, testing labs, and pharmacies that are knowledgeable about chronic Lyme disease and often about many other tick-borne diseases (TBD). Many of the doctors listed are often referred to as Lyme Literate Physicians/Doctors (LLMD). Tens of thousands of patients have successfully used the prior LDA system to locate Lyme and TBD resources.
Terms & Conditions and Guidelines
Because there is a negative political climate surrounding Lyme disease, many LLMDs do not want their names posted outright on the internet. LDA has tried to balance the doctors’ wishes with patients’ need to find a doctor. This new system is a result of that compromise and therefore:
Because of the limited number of physicians treating chronic Lyme disease nationwide, some states, and in some instances, entire regions, may not have any treating physicians who follow flexible treating approaches such as those in the International Lyme & Associated Diseases Society (ILADS) Guidelines, Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. In the event that the LDA Doctor Referral System © contains no Lyme or TBD resource listings in a given area, the closest possible option(s) will populate based on the location entered and specaialty/ies selected. The LDA appreciates any changes in provider information that you may find and make us aware of so we can investigate.
Some providers may not specifically treat Lyme and TBD but see patients who have symptoms associated with Lyme and TBD to address those specific symptoms. Contact the provider to confirm.
It is your responsibility to contact the provider’s office to confirm the current address, directions, nature of services provided, and all other provider information before you make an appointment.
DISCLAIMER: The Lyme Disease Association, Inc. provides referrals to health care providers who treat Lyme disease, and often other TBD, as a courtesy to those seeking Lyme Literate Physicians (LLMD). However, some of the providers included do not specifically treat Lyme and TBD but see patients who have symptoms associated with Lyme and TBD to address those specific symptoms. We do not evaluate the professional competence or qualifications of health care providers on our referral list or the costs of services provided. Accordingly, the LDA neither warrants nor endorses the health care providers contained on this list nor the quality of care you will receive from those providers. We do not make recommendations, only referrals. LDA does not receive any monies from physicians to be included on this list nor does LDA provide any monies to physicians. Because of the limited number of physicians treating chronic Lyme disease nationwide, some states, and in some instances, entire regions, may not have any treating physicians who follow flexible treating approaches such as those in the International Lyme & Associated Diseases Society (ILADS) Guidelines: Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. In the event that the Doctor Referral System contains no Lyme or TBD resource listings in a given area, the closest possible option(s) will populate based on the zip code entered and category/ies selected. The LDA appreciates any changes in provider information that you may find and make us aware of.
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We cannot guarantee that the information provided will be timely and accurate or that physicians on the list are accepting new patients, or that they accept insurance. The selection of a physician should be made by you after careful consideration. There are two approaches in the treatment of Lyme disease. Our list contains physicians who generally follow more flexible treatment approaches than those advocated by the Infectious Diseases Society of America (IDSA). LDA is not responsible for incorrect information on the website. BEFORE DOCTOR VISIT: Please contact the physicians’ offices directly to confirm their current address, directions, and any other necessary information before scheduling an appointment. Do not rely only on the maps provided on this site. The maps on LDA’s Doctor Referral System are for informational purposes and provide an approximate locality of the listing based on the addresses we are provided with at the time of site updates. Practitioners often relocate and addresses can change. Notification of changes in listed information can be updated on our Dr. Referral Contact Form. Thank you, Lyme Disease Association, Inc. (LDA)
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