Liotta, Lance A.

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Lance A. Liotta, MD PhD
University Professor
Co-Director Center for Applied Proteomics and Molecular Medicine
Medical Director Clinical Proteomics Lab
College of Science
George Mason University
10920 George Mason Circle
Room 2005 Life Sciences Laboratory Building
Manassas, Virginia 20110

Shedding of urinary tick pathogen-specific proteins in patients with tick borne diseases

Dr. Liotta is a University Professor in the College of Science, George Mason University. He received the MD and PhD (Bioengineering) from Case Western Reserve University, and fulfilled his residency at the National Institutes of Health (NIH), where he initiated a research program that, to date, has yielded more than 700 publications (Highly Cited Investigator), and more than 100 issued or allowed patents. At NIH Dr. Liotta was Chief, Laboratory of Pathology, Chief, Section of Tumor Invasion and Metastasis, and Deputy Director of NIH under NIH Director Bernadine Healy. He and Dr. Emanuel Petricoin of the FDA set up the first NIH/FDA Clinical Proteomics Program. In 2005 Mason recruited Dr. Liotta, and Dr. Petricoin (co-Directors), and their distinguished scientific team, to create the Center for Applied Proteomics and Molecular Medicine (CAPMM). The Mission of CAPMM is to discover disease mechanisms, invent new technologies, educate the scientists of the future, and translate knowledge to help patients through prevention, early detection, and treatment. Dr. Liotta has invented and patented, along with his laboratory co-inventors, high-impact technologies in the fields of diagnostics; microdissection (Laser Capture Microdissection), and proteomics (Reverse Phase Protein Microarrays, Biomarker Harvesting Nanoparticles, Preservation chemistries tissue, and Protein Painting to discover drug targets), that have been used to make broad discoveries.The Laser Capture Microdissection prototype is in the Smithsonian Collection.The CAPMM team applies these technologies, for example, to markers for early stage disease, accurate diagnosis of Tuberculosis and Lyme disease (Dr. Alessandra Luchini), individualized therapy for primary and metastatic cancer (Dr. Mariaelena Pierobon, Dr. Julia Wulfkuhle), therapy of premalignant breast cancer as a strategy for prevention (Dr. Virginia Espina), and anaccredited CAP/CLIA diagnostic lab for patient testing. Dr. Liotta has received numerous scientific awards, including election to AIBME Fellows status, the Arthur S. Flemming Award, the NIH Award of Merit, the Surgeon General’s Medallion, and the 2015 Virginia SHEV award for Research and Scholarship.

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This activity is supported by independent educational grants from:

Steven & Alexandra Cohen Foundation

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