William Robinson, MD, PhD
Professor of Medicine (Immunology and Rheumatology)
Staff Physician, VA Palo Alto
Palo Alto, CA
Protective and Pathogenic B Cell Responses in Lyme Disease
The Robinson laboratory works in the fields of B cell biology, autoimmunity and inflammation. Dr. Robinson pioneered development of protein arrays, lipid arrays, and high-throughput sequencing approaches to identify the targets of antibody responses, investigate mechanisms underlying disease, and to develop novel therapeutic approaches. Dr. Robinson co-founded the Stanford Human Immune Monitoring Center, serves on the editorial boards of several journals, and serves on the Board of Directors of the American College of Rheumatology and the Federation of Clinical Immunology Societies. He is an inventor on 23 patent applications, and technologies developed in his Stanford and VA laboratories have been licensed to nine companies in the biotechnology industry. Dr. Robinson was elected to the American Society for Clinical Investigation and the Henry Kunkel Society. Dr. Robinson received his MD and PhD degrees from Stanford University, and completed his clinical training in internal medicine at UCSF.
Conference Lecture Summary
We are applying immune repertoire sequencing to characterize the B cell and antibody response following Borrelia burgdorferi infection and in post-treatment Lyme disease syndrome (PTLDS). We show that robust B cell responses producing anti-Borrelia burgdorferi antibodies are associated with return to health following acute infection.