Elizabeth L. Maloney, MD, reviews the US trial evidence on EM rashes, problems of the IDSA recommendations considering that evidence, and provides evidence-based patient-centered strategies for managing patients with EM. “The EM rash is the hallmark finding of early disease,” along with other symptoms. “In light of the physical and financial costs, identifying and promoting highly effective therapeutic interventions for US patients with erythema migrans (EM) rashes that return them to their pre-infection health status should be a priority.”
Peer Reviewed Articles
This section contains articles published in peer reviewed literature on Lyme and other tick-borne diseases, and on COVID 19. Articles are written by experts, and then several other experts in that field will review the article and send back comments/concerns to authors. Articles are sometimes changed/clarified to address the issues that are raised in order to be published. Not all info in peer-reviewed journals is reviewed such as editorials, letters, book reviews.
The LDA is providing the articles in this section for your information. The articles included express the findings and opinions of the authors and are not necessarily those of the the LDA.
Data from a survey of respondents with self-reported tick bite encounters who concurrently reported a clinical or serological Lyme disease (LD) diagnosis from non-endemic states for Lyme disease was published in the journal Healthcare, June 21, 2021. Focusing on Texas, which due to large size, diverse climate, and ecological conditions, reflects environments that promote ticks, […]
A study published in PLOS Pathogens by Marisela M. Davis, et al. furthers understanding of the B. burgdorferi cell envelope and pathogenesis. The results highlight the plasticity of bacterial proteins and uncover some of the ways they may change how they perform a task despite no change in their basic biological function.
Frontiers in Neurology, 10 May 2021, published a study examining multiple molecular detection techniques to effectively identify Borrelia burgdorferi in the autopsy specimens of a patient with a history of neurocognitive disease. The individual was a post-mortem donor from the brain repository of the Lyme and Tick-Borne Diseases Research Center at the Columbia University Irving Medical Center.
Ohio State University researchers have just published on their creation of nanobodies which target the protein that causes E. chaffeensis bacteria to be extremely infectious. It is thought that these nanobodies can be developed as a new or complementary therapy for human monocytic ehrlichiosis as well as other tick-borne diseases that are caused by intracellular infections, infections that can be fatal if left untreated or undertreated.
Any woman who has Lyme disease and is considering becoming pregnant or who is pregnant, or who is bitten by a tick during pregnancy, should see a Lyme disease doctor, one who understands the serious medical implications of Lyme during pregnancy. The Lyme bacteria, Borrelia burgdorferi, can cross the placenta and can cause death of […]
An April 14, 2021 PLOS 1 study, Cynthia Otto et al., 2021, suggests that specially trained dogs can sniff out COVID-19 samples with 96% accuracy. The study, “Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study,” comes out of the University of Pennsylvania School of Veterinary Medicine Working Dog Center. […]
A new study was published April 23, 2021, in Applied and Environmental Microbiology, “Examining prevalence and diversity of tick-borne pathogens in questing Ixodes pacificus ticks in California,” by Daniel Salkeld, et al. This is the first study to characterize bacteria carried by ticks in the chaparral in beach areas. The findings were unexpected: black-legged ticks […]
Findings from this sample of patients showed that this group of patients reported more severe symptoms than the general population as well as reporting higher than other clinical sample groups including cancer patients and chronic pain patients, and for symptoms of fatigue, women reported higher than men.