Katherine Leavey, et al., published, “Lyme borreliosis in pregnancy and associations with parent and offspring health outcomes: An international cross-sectional survey” in Frontiers in Medicine on November 3, 2022. Data regarding the health outcomes of people infected with Lyme disease during pregnancy is limited, as is perinatal transmission to their fetus, and the long-term effects on their children…
Peer Reviewed Articles
This section contains articles published in peer reviewed literature on Lyme and other tick-borne diseases, and on COVID 19. Articles are written by experts, and then several other experts in that field will review the article and send back comments/concerns to authors. Articles are sometimes changed/clarified to address the issues that are raised in order to be published. Not all info in peer-reviewed journals is reviewed such as editorials, letters, book reviews.
The LDA is providing the articles in this section for your information. The articles included express the findings and opinions of the authors and are not necessarily those of the the LDA.
Arick P.Sabin, et al., published “Clinical evaluation of a Borrelia modified two-tiered testing (MTTT) shows increased early sensitivity for Borrelia burgdorferi but not other endemic Borrelia species in a high incidence region for Lyme disease in Wisconsin” in Diagnostic Microbiology and Infectious Disease on November 9, 2022,* (version of record). Recently, a modified two-tiered testing algorithm (MTTT; ZEUS Scientific) for Borrelia burgdorferi was cleared by the FDA. This led the researchers to assess the algorithm to verify Lyme disease as well as evaluate the results in comparison to those acquired using standard two-tiered testing (STTT).
Daniel J.B. Clarke, et al, published “Gene set predictor for post-treatment Lyme disease” in Cell Reports Medicine on November 15, 2022. The researchers enrolled 152 study participants, each with symptoms of post-treatment Lyme disease (PTLD), to analyze their peripheral blood mononuclear cells (PBMCs) with RNA sequencing (RNA-seq). RNA-seq data from 72 individuals with acute Lyme disease and 44 uninfected controls were incorporated to examine variations in differential gene expression.
Timothy C. Saylor, et al., published “Borrelia burgdorferi, the Lyme disease spirochete, possesses genetically-encoded responses to doxycycline, but not to amoxicillin” in PLOS ONE on September 30, 2022. The study examines whether B. burgdorferi responds to antibiotic stresses by creating proteins that provide a safeguard against antibiotics, and therefore changing its transcription profile, as some species of bacteria have been found to do.
Michael Lum, et al., published “Procalcitonin as a Potential Biomarker in the
Study of Babesiosis Caused by B. microti” in Pathogens on October 23, 2022. Thirty-three acute babesiosis cases from 2012 through 2019 were collected retroactively from Long Island-based Stony Brook University Hospital (SBUH) and Stony Brook South Hampton Hospital (SHH). The cases were cross-referenced for necessary ICU admission, and procalcitonin levels were measured using BRAHMS Elecsys assay at SBUH and BRAHMS Architect assay at SHH.
Eric L. Siegel, et al., published a study examining a potential new tick repellent method titled “Spatial repellents transfluthrin and metofluthrin affect the behavior of Dermacentor variabilis, Amblyomma americanum, and Ixodes scapularis in an in vitro vertical climb assay” in PLOS ONE on November 8, 2022. The researchers assessed the efficacy of those repellents against Dermacentor variabilis, Amblyomma americanum, and Ixodes scapularis adult, female ticks by designing an in vitro vertical climb assay to measure spatial repellency.
Shannon Baron, et al., published, “Unresolved Heart Block in Lyme Carditis: A Case Report” in Cureus on September 27, 2022, chronicling the case of a man who was admitted to the emergency department with a day-long history of syncopal episodes.
Samudyata, et al., published the study “SARS-CoV-2 promotes microglial synapse elimination in human brain organoids” in Molecular Psychiatry on October 5, 2022, to better understand what COVID-19 can do to the human brain. Neuropsychiatric symptoms occur often in both the acute and post-acute stages of SARS-CoV-2 infections, however, the mechanisms of these manifestations have remained unknown.
Skyler M. Kerr, et al., published “Statewide survey of medically important ticks on white-tailed deer, Odocoileus virginianus Zimmerman, in Alabama, U.S.A.” on October 18, 2022, in Journal of Vector Ecology*. The researchers assessed tick fauna found on deer that were located in Alabama from a state-wide study taking place during hunting seasons 2019-2020 and 2020-2021. *Vol. 47, No. 2, December 2022 issue.
Cherie L. Marvel, et al., published “A multimodal neuroimaging study of brain abnormalities and clinical correlates in post treatment Lyme disease” in PLOS ONE on October 26, 2022. The objective was to uncover evidence that may help to explain the cause of cognitive complaints commonly reported amongst patients with post treatment Lyme disease (PTLD).