The study “Borrelia burgdorferi Sensu Stricto DNA in Field-Collected Haemaphysalis longicornis Ticks, Pennsylvania, United States” was recently published in the Centers for Disease Control & Prevention (CDC) Emerging Infectious Diseases. Pennsylvania has the highest number of reported Lyme disease cases in the US.
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This new summary article by employees of the CDC, presents the first county-level map of the distribution of Lyme disease spirochetes in host seeking Ixodes ticks between 2004-2019 in the contiguous United States. Data compiled for this summary was from literature searches; publicly available tick-borne pathogen surveillance databases (ArboNet Tick module); and internal CDC pathogen […]
Does Bartonella Contribute to the Occurrence of Cutaneous Lesions and Neuropsychiatric Symptoms in Patients?
Results of the study, “Bartonella Associated Cutaneous Lesions (BACL) in People with Neuropsychiatric Symptoms” was recently published in the journal, Pathogens, as part of the special issue, “The Evolving Biomedical Importance of Bartonella Species Infections.” The study’s authors describe Bartonella spp. test results for participants who reported neuropsychiatric symptoms, with a majority reporting the concurrent incidence of cutaneous lesions.
The CDC published, in the February edition of its “Emerging Infectious Diseases,” two new papers pertaining to Lyme disease case numbers. CDC indicates that the researchers found ~ 476,000 people are diagnosed with and treated for Lyme disease each year in the U.S. This is a 59% increase from their previous estimate of ~300,000. Also, CDC posted a new page to its website, Syndromic Surveillance of Emergency Department Visits for Tick Bites, showing tick bites by time, age/sex, and region.
Virulence of Borrelia involves multiple channels for transmission and establishment in multiple tissues, as well as evasion of the host immune responses. The bacteria undergo significant changes in gene expression and multiply and spread once transmitted to the host. These changes induce inflammatory responses that, in humans, result in clinical signs and symptoms of disease. In […]
Peter A. McCullough, M.D., M.P.H., Vice Chief of Internal Medicine, Baylor University Medical Center, et al. published an article in the American Journal of Medicine, August 2020: “Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection.” The authors have proposed an algorithm based on age and comorbidities that allows for a large proportion to be monitored and treated at home during self-isolation with the aim of reducing the risks of hospitalization and death.
In a retrospective review on the use of Disulfiram as a repurposed drug in the treatment of Lyme and Babesiosis, most patients experienced benefits with regard to their symptoms. It was found that although patients on high dose experienced higher risk for adverse reactions than the low dose patients, they were also more likely to […]
A new study published in Infectious Disease Modelling examines the relationships between incidence, prevalence, and total infection burden for Lyme borreliosis (LB) using sentinel canine and human seroprevalence data.
The researchers developed two models to estimate LB cases. One analyzed seroprevalence of Borrelia infections in human samples, applying corrections for false negative and false positive results from published test sensitivity and specificity measures.
A review article has just been published by the Journal of Medical Entomology describing the ticks and tick-borne diseases of Colorado which includes tick-host associations, geographic distributions and medical/veterinary importance. In this article, 28 species of endemic ticks in Colorado are described as well as an additional 5 species that are occasionally detected, 13 exotic […]
A new study lead by researchers from the University of California Los Angeles (UCLA) analyzed data from the MyLymeData patient registry. The Registry, with over 13,000 enrolled patients, is a project of the non-profit LymeDisease.org.
The researchers used machine learning techniques and analyzed more than 2,000 patients with chronic Lyme disease (CLD) from the database to identify key features associated with improved patient response. They found that the extended use of antibiotics was an important element of improved health.