The New England Journal of Medicine, Journal Watch, reports on phase 2/3 clinical trial results of combination treatment with two oral drugs against SARS-CoV-2 (COVID 19). Nirmatrelvir functions to inhibit a SARS-CoV-2 protease which is critically important to viral replication. Ritonavir, is an antiviral used to treat HIV infections. When ritonavir is given in combination […]
This Research Articles section includes articles on cutting edge research or on research which has been conducted on already existing research to either substantiate it or question its findings. The Peer Review Articles submenu sections includes only research in peer-reviewed journals–in which a panel of experts in the same field as the authors reviews the articles prior to publication to ensure scientific quality. The Professional/Govt Articles submenu contains articles by professionals or government without those articles going through the peer-review process.
Researchers have found that both male and female specimens of a species of soft tick in Africa, Argas brumpti Neumann, show renowned sustained survival, with some individuals living greater than 26 years. This large soft tick species occupies dry habitats of eastern and southern Africa and feeds on various small and large mammals, lizards, and […]
This study evaluates the effectiveness of tafenoquine (antimalarial primaquine analog) for treatment in an immunocompromised patient infected by a strain of Babesia microti that was partially resistant to both azithromycin and atovaquone treatment.
In a letter to the Editor of the American Journal of Medicine, Elizabeth Maloney, MD responds to the new guidelines for erythema migrans (EM) rash. She writes: “If the primary treatment goal for managing patients with erythema migrans (EM) rashes is to restore patients to their pre-Lyme health status, then the guidelines endorsed by Auwaerter […]
According to a new study conducted by Swedish researchers at Lund University, the messenger RNA (mRNA) from Pfizer’s COVID-19 vaccine is able to enter human liver where it triggers the cell’s DNA, inside the nucleus, to increase the production of the LINE-1 gene expression to make mRNA. Results of the study showed rapid up-take of […]
In this article, researchers aimed to identify areas of potential suitable habitat for Ixodes pacificus (western blacklegged tick) within Alaska. Although not considered endemic, I. pacificus has been collected recently from domestic animals in Alaska. Questions remain regarding the ability for survival and reproduction in Alaska if this species is introduced to the high-latitude climate […]
ACS Nano has published the results of a study demonstrating the link between human plasma and innate immunity and pointing at blood as a source of vital antimicrobials. Researchers examined three peptides sourced from the human apolipoprotein B (residues 887–922). In vitro and animal models found the peptides to be highly effective against the drug-resistant microbes, Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococc.
In this article published in FEMS Microbiology Reviews, researchers provide an overview of the current and future perspectives for diagnosis of several species of difficult to detect Gram-negative bacteria. Investigators discuss the zoonotic and vector-transmitted bacteria, Anaplasma spp., Bartonella spp., Coxiella burnetii, Orientia spp., and Rickettsia spp. These bacteria are strongly adapted to the infected host which impedes growth […]
In this study, investigators evaluated the potential for deer as zooprophylactic or “dilution” hosts for Borrelia burgdorferi in tick vectors. Zooprophylaxis is the diversion of vector bites from the reservoir host to other hosts. As deer are considered to be incompetent reservoirs of B. burgdorferi in the northeastern US, it was hypothesized that they may […]
This article summarizes a review of the literature regarding reported cases of prosthetic joint infections (PJI) caused by Lyme in knee replacements. The goal of the review was to initiate the development of a treatment strategy for these infections. Investigators found only five cases of Lyme PJI in the literature after searching Scopus and PubMed […]