Peter A. McCullough, M.D., M.P.H., Vice Chief of Internal Medicine, Baylor University Medical Center, et al. published an article in the American Journal of Medicine, August 2020: “Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection.” The authors have proposed an algorithm based on age and comorbidities that allows for a large proportion to be monitored and treated at home during self-isolation with the aim of reducing the risks of hospitalization and death.
This Research Articles section includes articles on cutting edge research or on research which has been conducted on already existing research to either substantiate it or question its findings. The Peer Review Articles submenu sections includes only research in peer-reviewed journals–in which a panel of experts in the same field as the authors reviews the articles prior to publication to ensure scientific quality. The Professional/Govt Articles submenu contains articles by professionals or government without those articles going through the peer-review process.
In a retrospective review on the use of Disulfiram as a repurposed drug in the treatment of Lyme and Babesiosis, most patients experienced benefits with regard to their symptoms. It was found that although patients on high dose experienced higher risk for adverse reactions than the low dose patients, they were also more likely to […]
A new study published in Infectious Disease Modelling examines the relationships between incidence, prevalence, and total infection burden for Lyme borreliosis (LB) using sentinel canine and human seroprevalence data.
The researchers developed two models to estimate LB cases. One analyzed seroprevalence of Borrelia infections in human samples, applying corrections for false negative and false positive results from published test sensitivity and specificity measures.
A review article has just been published by the Journal of Medical Entomology describing the ticks and tick-borne diseases of Colorado which includes tick-host associations, geographic distributions and medical/veterinary importance. In this article, 28 species of endemic ticks in Colorado are described as well as an additional 5 species that are occasionally detected, 13 exotic […]
A new study lead by researchers from the University of California Los Angeles (UCLA) analyzed data from the MyLymeData patient registry. The Registry, with over 13,000 enrolled patients, is a project of the non-profit LymeDisease.org.
The researchers used machine learning techniques and analyzed more than 2,000 patients with chronic Lyme disease (CLD) from the database to identify key features associated with improved patient response. They found that the extended use of antibiotics was an important element of improved health.
Richard Horwitz, MD, et al., have published a new case study and retrospective chart review of 40 patients on double dose dapsone combination therapy (DDD CT) in the journal Antibiotics.
The study found that of the 40 patients analyzed, an 8-week course of dapsone combined with doxycycline and rifampin effectively improved symptoms in 98% of patients, as well as led to long-term remission in 45% of the total patients studied, even though most of the individuals were ill for a decade or longer.
The results of a study to collect ticks from Pike County, Pennsylvania, conducted by the Northeast Wildlife DNA Laboratory of East Stroudsburg University included real time PCR analysis of ticks countywide. The county was divided into 9 grids, each with several collection sites. The sites were based on use by community members and presence of […]
A study published in the journal Diagnostic Microbiology and Infectious Disease addresses the observed negative effects of the COVID-19 pandemic on the timely diagnosis of tick-borne infections (TBD) in three adult patients.
New in vitro study on dapsone (diaminodiphenyl sulfone), and dapsone combination therapy (DDS CT) was just published by Dr. Richard Horowitz et al. and provides hope of effective treatment for patients with persistent Lyme disease. The study is suggestive that dapsone combination therapy may well characterize both a novel and successful option to treat Borrelia […]
In a recent Rutgers University-led study, researchers identified Carios kelleyi, a “soft” tick species associated with bats, for the first time in New Jersey. This parasite, of almost exclusively bats, is thought widespread in the US (as well as parts of Canada, Mexico, Costa Rica, and Cuba), with known occurrences in 29 of the 48 […]