Blocking Tick-Borne Infection with Nanobodies
Ohio State University researchers have just published an article on their creation of nanobodies which target the protein that causes E. chaffeensis bacteria to be extremely infectious. Nanobodies are small molecules that can be designed to mimic the function and structure of antibodies and may be the solution to inhibit tick-borne bacterial infections that remain inaccessible by most current antibiotics due to the fact that they reside and replicate inside human immune cells.
Researchers conducted a number of experiments in both mice and cell cultures which identified one specific nanobody that could suppress E. chaffeensis infection by blocking three ways the protein enables the bacteria to commandeer immune cells. It is thought that these nanobodies can be developed as a new or complementary therapy for human monocytic ehrlichiosis as well as other tick-borne diseases that are caused by intracellular infections, infections that can be fatal if left untreated or undertreated.
Read Science Daily article here.
Read full text Ohio State research article here.
Read more LDA posts on Ehrlichiosis here.