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2012 LDA Conference Summary

Conference Reveals Lyme Can Persist After Short-Term Therapy

Animal models confirm survival of Lyme spirochete in spite of treatment

By Jessica Thomson *

JessThomsonAn eclectic group of scientists, researchers, physicians, veterinarians and molecular biologists assembled in Philadelphia to present scientific research and clinical papers for Lyme and other tick-borne diseases last September.

The purpose of the continuing medical education (CME) scientific conference is to educate the physicians and researcher attendees about Lyme and other tick-borne diseases. The knowledge gleaned is used to improve their medical practices if they are clinicians and is used to foster collaborations with others if they are researchers The public and advocate attendees are able to disseminate scientifically and clinically established information to patients and may select new research projects to fund based on what the conference faculty has presented.

Brian Fallon, MD, MPH
Fallon2Dr. Fallon, conference director and co-chair, said that the conference unites ivory tower researchers “with the people.” Dr Fallon serves as Director of Columbia University Lyme & Tick-Borne Diseases Research Center. “The conference also brings together the researchers with the clinicians, so the researchers can hear first-hand what the clinicians are struggling with. And, it fosters collaboration among researchers,” Fallon added.

“If I were a patient, I’d be most excited about knowing that researchers are taking this disease seriously and coming together to prove Borrelia’s persistence despite antibiotics. Until recently, that was considered to be an impossibility.”

The publication of research helps the Lyme community contest the theory that it was extraordinarily unlikely for persistent Lyme to occur post treatment. “Now we have these major studies published where nobody can dispute the persistence of the organism,” Fallon said.

Stephen W. Barthold, DVM, PhD
BartholdDr. Barthold, Director, Center for Comparative Medicine at UC Davis, has been involved in Lyme disease research since its discovery in Connecticut over 35 years ago. His training as a pathologist and his lengthy career as a veterinarian are an important foundation for examining Lyme disease. He explained that being a veterinarian allows him to examine the life stages and variation of host responses of Borrelia in animals, then interpret and apply the results to humans. “Animal model studies are critical to get a handle on what’s going on with Lyme disease. Unless you understand the life stages of Borrelia and the variation of host response, you’ll never get a true understanding,” he said.

Dr. Barthold, keynote speaker and conference co-chair, said he helped choose presenters for the conference from the Lyme scientific community he has worked with over the years, calling them “a wonderful group with wonderful diversity.” Speaking of his fascination with the complexity of the Lyme disease organism, he said, “It truly needs multiple disciplines looking at it from multiple perspectives.”

Lyme disease draws a wide range of medical and research specialists, because it is as much an ecological disease as an individual disease, he explained. He spoke about the global migration of other diseases spreading to different climatic territories due to global warming. For example, a cow and sheep disease called Blue Tongue is also affected by environmental changes.

Dr. Barthold called Lyme disease “tough to crack.” With multiple studies conducted among multiple labs with multiple antibiotic treatments, all evidence points to the Lyme bacteria as very persistent, he said.  Dr. Bathold explained that most diseases take a long time to gain momentum for positive change, and he understood the sense of frustration among members of the Lyme community who have been asking for amended diagnostic and treatment protocols for years. “Medical science is like a fault zone, and it sticks (in one place) for awhile,” he said.

Drawing on AIDS as an example of another disease that took time to be properly recognized, Dr. Barthold spoke about the disconnect between the patient experience and science generalizing without enough evidence. He believes that the restrictive IDSA Lyme guidelines can change when everyone learns to keep an “open mind” when approaching the disease.

He said that the division of the medical community is nothing new. Medical history is full of stories where the medical community becomes dogmatic and refuses to change its opinion even when evidence is showing the truth. “It’s only when there’s enough collective evidence and people behind it that the disease can move forward,” he said. “Lyme disease is at a crucial point where it’s starting to move forward,” he added.

According to Dr. Barthold, progress in Lyme disease is also slow due to the multiple verifications and repetitions required in scientific research. He feels that the current political environment is killing the advancement of science. Today’s science graduates are not interested in launching a career in Lyme research because there is an uphill battle getting grants, he said. Of the half dozen Lyme disease grants that are proposed each year, the chances of even one of them getting funded is very slim “because if a grant is in any way controversial, that’s enough to stop funding,” said Dr. Barthold. He thinks the only way to change matters is to pressure Congress to give some attention to the way the government is awarding grants.

Dr. Barthold urged the medical community to get out of the dark ages in their thinking about antibiotics. He explained that while antibiotics can cure infection for streptococcus, it is different for Lyme disease because Borrelia is an infection that can evade a perfectly good host immune response as part of its normal biology. That is the problem. The surviving forms of Borrelia are not able to be cultivated, however, so they are different in some way, he said.

Janis Weis, PhD
WeisJanis Weis, who has been researching genetics in mice, sometimes feels distant from patients, but “being around patients and advocates at the conference was invigorating. It’s a reminder of why we’re doing all the work we do and makes me feel like I’m on the right track.” Weis spoke of the years of work behind each of the presentations at the conference. She was happy that finally there seems to be progress in understanding why symptoms are persistent, a concept finally being taken seriously because of the studies using animal models.

Weis’ mouse studies hold significance for patients because they serve as a model for chronic patients who have been treated with antibiotics but whose inflammation persists. Like humans, mice that get swollen joints and have similar pathology serve as a guide to human studies. Her studies have identified that mice once infected with Lyme disease lack an anti-inflammatory protein so they have an over-active immune response. While this over-active immune response clears the bacteria better from tissues, it also results in severe arthritis that persists even after the bacteria can no longer be detected.

Weis is most excited about the Transpogenesis work being done by Steven J. Norris, PhD, another conference speaker. She stated that it “could lead to new discoveries of bacterial genes that could be important for persistence. He’s looking at antigenic variation and how the bacteria evade the immune response.” Weis also learned from the work of LDA conference speaker Nicole Baumgarth, DVM, PhD, with B-cell subversion during Borrelia infection. Weis added that it is a novel concept to find that the IgG becomes more effective if you don’t have

C. Ben Beard, PhD
BeardC. Ben Beard, PhD, Chief, Bacterial Diseases Branch of the Vector-Borne Diseases, Centers for Disease Control and Prevention (CDC), believes the conference is “a great place for scientific minds to come together for honest conversations that can lead to increased trust”

Dr. Beard said he disagreed that Lyme disease is hard to catch and easy to cure. The CDC numbers in his presentation revealed that it’s the most common vector-borne disease in the country, the second most common reportable disease in the Northeast, the third most common in the entire East Coast and the sixth most common in the whole country, “which all prove that Lyme disease is easy to get,” he said.

Dr. Beard admits that even those figures are not accurate because a large number of patients are not being counted properly. He says that he wants the CDC to wake up and acknowledge that Lyme is an important disease. “Our view is there’s lots of tick-borne disease, but we’re not sure it’s [all] Lyme disease,” Dr. Beard said.

Dr. Beard spoke about the double-edged sword that accompanies accurate reporting. “When numbers go up we’re thinking we’ll get more money (for surveillance) but we’re also thinking it’s bad because we’re losing the battle (more people are becoming infected),” he said.

People complain about low surveillance numbers, but dr. Beard’s explanation is that their entire budget could be spent just on surveillance and it still might not be accurate or give them the information they need about how the disease is spreading. The CDC is focusing on 16 states where 97% of all Lyme cases are reported, so they can do a better job of counting, he said. The CDC cannot go into everyone’s backyard to count ticks, Dr. Beard explained. “We just do not have the resources,” he added.

As far as the CDC’s stance on the current number of Lyme cases in the US, he explained, underreporting ranges from three to 12 fold but in reality, the CDC has no idea of how much Lyme disease there is on a national level, which is an astonishing admission.

“[The CDC] is a pro-patient organization – what’s good for public health is good for the patient,” Dr. Beard said. He even calls himself a “Lyme activist.”

Monica Embers, PhD
EmbersDr. Monica Embers presented her findings of post-treatment persistence and sero-diagnosis of Lyme disease in monkeys. Her team has been investigating antibiotic efficacy in controlled animal studies because humans come with varied duration before diagnosis.

“There are lots of different genospecies in nature,” Dr Embers explained, “so we’re doing what we can to try to understand, using the right kind of model systems where infection is controlled, treatment is controlled, and we can really look inside.” Dr. Embers said she was pleased to see that “there’s real momentum, things are really moving along” in research studies for Lyme disease.


NOTE: Ms.Thomson wrote the article for the Lyme Disease Association based on presentations from Faculty at the 2012 conference where she was in attendance and also on post presentation interviews with speakers she taped for the LDA.




2013 Conference Faculty Biographies

Click on name to link to bio: 

John Aucott, MD Brian A. Fallon, MD, MPH Richard Rhee, MD, FAAN
Nicole Baumgarth, DVM, PhD Leila Zackrison, MD Sam Shor, MD, FACP
Edward B. Beitschwerdt, DVM A.T. Charlie Johnson, PhD RW (Bill) Stich, MD, PhD
George Chaconas, PhD Kenneth B. Liegner, MD Ellen Stromdahl, MS, BCE
Madeleline W. Cunningham, PhD Elizabeth Maloney, MD Ernest Visconti, MD 
Sam T. Donta, MD Judith Miklossy, MD, PhD, DSc

 


 

AucottJohn Aucott, MD
Assistant Professor in Medicine, Johns Hopkins Hospital
Johns Hopkins University, Baltimore, MD

Private Practice: Board Certified, Internal Medicine
10755 Falls Road, Suite 200
Lutherville, MD, 21093

Erythema Migrans (EM) in Lyme Diagnosis

Dr. Aucott is a graduate of the University of California at Berkeley where he was elected to the membership of Phi Beta Kappa. He attended the Johns Hopkins University School of Medicine, and is a Diplomate of the American Board of Internal Medicine with sub-specialty training in Infectious Disease and Geographic Medicine at University Hospitals of Cleveland. He served as the Section Head for General Internal Medicine and the Residency Program Director at the Cleveland Veterans Affairs Medical Center while on the faculty at Case Western Reserve University School of Medicine from 1989-1996. He was promoted to Associate Professor of Medicine in 1995.

In 1996, Dr. Aucott returned to Baltimore to join the clinical Faculty of Medicine at Johns Hopkins School of Medicine where his focus has been on clinical translation research in Lyme disease. He is currently the Principal Investigator for the prospective cohort study, SLICE, examining the impact of acute Lyme disease on long-term health outcomes and immune function.

Dr. Aucott is the founder of the Lyme Disease Research Foundation, a public non-profit organization founded to promote research and education in Lyme disease. He has lectured through programs sponsored by Johns Hopkins Divisions of Medicine and Infectious Diseases, the American College of Physicians, and other major medical programs in the United States. He has published numerous articles in the field of infectious diseases and Lyme disease.  

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BaumgartNicole Baumgarth, DVM, PhD
Center for Comparative Medicine
University of California, Davis
County Rd 98 & Hutchison Dr.
Davis, CA 95616

B cell subversion during Borrelia infection – a persistence strategy

Nicole Baumgarth is a DVM, PhD and Professor of Immunology at the Center for Comparative Medicine, University of California, Davis. She is also the Chair of the Graduate Group in Immunology there. Dr. Baumgarth’s research encompasses studies on the regulation of immune responses to infections and B cell biology. Much of her recent work has focused on the regulation of B cell responses and B cell subset responses using mouse models to two very different pathogens and immune responses: Acute influenza virus infection, an infection that fully resolves and induces highly protective and long-lived B cell-mediated immunity, and B cell responses to Borrelia burgdorferi, a bacterial spirochete and the causative agent of Lyme disease. Infections with B. burgdorferi induce strong B cell responses, however, those responses to not result in clearance of the infection. By contrasting a successful with a not-successful B cell response her group hopes to uncover important immune regulatory mechanisms that shape the quality of the B cell response.

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BreitschwerdtEdward B. Breitschwerdt, DVM
Professor of Medicine and Infectious Diseases
North Carolina State University College of Veterinary Medicine
Adjunct Professor of Medicine, Duke University Medical Center
Diplomate, American College of Veterinary Internal Medicine (ACVIM)
Raleigh, NC

Bartonelliosis:  A One Health Approach to a Persistent Blood-Borne Infection 

Dr. Edward B. Breitschwerdt is a professor of medicine and infectious diseases at North Carolina State University College of Veterinary Medicine. He is also an adjunct professor of medicine at Duke University Medical Center, and a Diplomate, American College of Veterinary Internal Medicine (ACVIM).  Dr. Breitschwerdt directs the Intracellular Pathogens Research Laboratory in the Center for Comparative Medicine and Translational Research at North Carolina State University. He also co-directs the Vector Borne Diseases Diagnostic Laboratory and is the director of the NCSU-CVM Biosafety Level 3 Laboratory.

A graduate of the University of Georgia, Breitschwerdt completed an internship and residency in Internal Medicine at the University of Missouri between 1974 and 1977. He has served as president of the Specialty of Internal Medicine and as chairman of the ACVIM Board of Regents. He is a former associate editor for the Journal of Veterinary Internal Medicine and was a founding member of the ACVIM Foundation.

Breitschwerdt’s clinical interests include infectious diseases, immunology, and nephrology. For over 20 years, his research has emphasized vector-transmitted, intracellular pathogens. Most recently, he has contributed to cutting-edge research in the areas of animal and human bartonellosis. In addition to authoring numerous book chapters and proceedings, Dr. Breitschwerdt’s research group has published more that 300 manuscripts in peer-reviewed scientific journals. In 2012, he received the North Carolina State University Alumni Association Outstanding Research Award and in 2013 he received the Holladay Medal, the highest award bestowed on a faculty member at North Carolina State University

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ChaconasGeorge Chaconas, PhD
Canada Research Chair in the Molecular Biology of Lyme Borreliosis
Department of Biochemistry & Molecular Biology
The University of Calgary
Calgary, AB
Canada

Live Imaging Studies of Dissemination of the Lyme Spirochete in Mice

George Chaconas obtained his Ph.D. in the Division of Medical Biochemistry at the University of Calgary in Alberta, Canada and did postdoctoral work Cold Spring Harbor Laboratory in New York. He subsequently took a faculty position in the Department of Biochemistry at the University of Western Ontario. His laboratory focused on the molecular mechanism of DNA transposition or “how jumping genes jump”. In 1999-2000, with the help of a Guggenheim Fellowship, George’s research interests took a turn through a sabbatical at the NIH Rocky Mountain Labs in Montana where he began working on the Lyme disease pathogen Borrelia burgdorferi. In 2002 he took a position in the Department of Biochemistry & Molecular Biology and the Department of Microbiology & Infectious Diseases at the University of Calgary in Alberta, Canada where he is currently Professor, Scientist of the Alberta Heritage Foundation for Medical Research and holds the Canada Research Chair in the Molecular Biology of Lyme Borreliosis.

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CunninghamMadeleine W. Cunningham, PhD
George Lynn Cross Research Professor
Presbyterian Health Foundation Presidential Professor
Microbiology and Immunology
Director, Immunology Training Program
University of Oklahoma Health Sciences Center
Biomedical Research Center
Oklahoma City, OK

Anti-Neuronal Antibiodies in Lyme Disease

Dr Cunningham received her PhD in1973 at University of Tennessee-Memphis in Microbiology and Immunology. She studied for 3 years as a postdoctoral fellow in Protein Studies at the Oklahoma Medical Research Foundation in Oklahoma City. Following her postdoctoral fellowship, she accepted a position at the University of Oklahoma Health Sciences Center & has maintained an active laboratory since 1980.
Research in Dr. Cunningham’s laboratory investigates molecular mimicry, autoimmunity and infection in inflammatory heart diseases and in behavioral and movement disorders.

Her laboratory studies autoimmunity, infection and behavior which is manifest in diseases such as Sydenham’s chorea and in pediatric autoimmune neuropsychiatric disorder following group A streptococcal infection (PANDAS). Using human monoclonal antibodies, the work has identified antibody mediated neuronal cell signaling as a potential basis for movement or neuropsychiatric disorders and potentially other brain related disorders, including obsessive compulsive disorder, Tourette’s Syndrome and Tics. These diseases including PANDAS are under investigation to determine the relationship of autoantibodies which bind to brain antigens or signal in the brain to development of symptoms. Investigation of Lyme disease for autoantibodies against the brain has been funded by the Lyme Disease Association and the study is underway in her laboratory. She was funded by the National Institute of Mental Health Bench to Bedside Grant to investigate autoantibodies in PANDAS in the recent IVIG trial.

In addition, her laboratory investigates the pathogenesis of rheumatic carditis, a sequela of group A streptococcal pharyngitis, and of myocarditis, a complication that can follow coxsackieviral infections. Rheumatic carditis affects the heart valves, while myocarditis results in the destruction of the myocardium. Studies in myocarditis currently are supported by the National Heart Lung and Blood Institute and are focused on a 5 year longitudinal study of T cell subsets and monocyte responses in patients with myocarditis who develop cardiomyopathy. Translational research using human monoclonal antibodies and T cell clones from disease have provided clues about pathogenic mechanisms in disease. Other work funded by the National Heart Lung and Blood Institute includes studies of the pathogenesis of hypoplastic left heart syndrome in infants.

Dr. Cunningham has served many years on review panels at the National Institutes of Health and served on the National Research Committee at the American Heart Association. She was a representative of the United States for the US-Indo Vaccine Action Program. She was elected an AAAS fellow and ASM fellow. She received a National Heart Lung and Blood Institute Research Career Development Award and Merit Award. She has been supported by the NIH for the past 25 years. She is the Director of the NIAID supported Immunology Training Program at the University of Oklahoma Health Sciences Center. She lectured on the effects of autoantibodies on the brain in the Presidential Symposium at the American Association of Immunologists in 2010. Dr Cunningham is the author of over 100 publications.

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DontabSam T. Donta, MD
Consulting Physician in Infectious Diseases Fairmouth Hospital
Falmouth, MA

Issues in the Treatment of Lyme Disease

Dr Donta grew up in Western Pennsylvania, received his BS from Allegheny College, his MD from Albert Einstein College of Medicine, did an internship/residency in Internal Medicine at U. of Pittsburgh Hospitals, served in Air Force at Otis AFB, MA, did post-doctoral training in Biochemistry at Brandeis, and Fellowship in Infectious Diseases at Boston Univ.

He went to U. of Iowa where he became Professor of Medicine and Chief of Infectious Diseases, then was at U. of Connecticut for 11yrs as Chief of ID, Chief of Medicine at VA, then moved to Boston University/Boston VA for 10yrs before his retirement.

His basic interests have been in microbial toxins, but he has also been involved in a number of clinical trials. For the last 25yrs, he has been interested in Lyme disease, and continues to have an active clinical practice in Falmouth, studying and treating patients with chronic Lyme disease and other multi-symptom disorders such as Chronic Fatigue Syndrome and Fibromyalgia.

He is the author of 100+ publications on toxins, Lyme Disease, Gulf War Veterans’ Illnesses, and hopes to continue research in these areas.

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FallonBrian A. Fallon, MD, MPH (Course Co-Director)
Professor of Psychiatry
Director, Lyme and Tick-Borne Diseases Research Center,
Columbia University Medical Center
Director, Center for the Study of Neuroinflammatory Disorders & Biobehavioral Medicine, New York State Psychiatric Institute
New York, NY

Lyme Disease Or Hypochondriasis

Brian A. Fallon, MD, MPH. Dr. Fallon is director of the Lyme & Tick-borne Diseases Research Center at Columbia University Medical Center where he leads a team focused on biomarkers, diagnostics and treatment of chronic Lyme symptoms. His team’s recent work has included the testing of novel diagnostic assays in a large community study, as well as collaborating on new test development using the Columbia Lyme Center biorepository. His team’s work on Lyme encephalopathy led to the discovery of hundreds of unique proteins present in the CSF of Lyme patients but not in the CSF of patients with chronic fatigue syndrome or healthy controls. His team’s current focus is on clarifying the immunologic profile and neural circuitry of patients with persistent symptoms. His team is also investigating the CNS metabolic effects of intravenous ceftriaxone using MR Spectroscopy to probe glutamatergic transmission. Dr. Dwork in his Center is examining the neuropathologic findings in post-mortem studies of patients with chronic Lyme symptoms. Dr. Moeller in his Center is examining the interaction between peripheral immunologic markers, central immune markers, and brain neurocircuitry among patients with chronic symptoms with the goal of identifying of biomarkers to help guide treatment recommendations. Dr. Fallon serves on the editorial and review board of three journals, has lectured and published widely, and most recently has led an international team for the American Psychiatric Association’s revision of DSM-5 to clarify the prevalence of illness anxiety in the general population.

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JohnsonA.T. Charlie Johnson, BS, MS, PhD
Professor of Physics and Astronomy
Associate Chair for Graduate Affairs

Secondary Appoints in: Materials Science & Engineering and Electrical & Systems Engineering
University of Pennsylvania
Philadelphia, PA 

Detecting Lyme disease using antibody-functionalized single-walled carbon nanotube transistors

A. T. Charlie Johnson received a B.S. from Stanford University, and a M.S. and Ph.D. from Harvard University, all in Physics. He was a European Union ESPRIT Postdoctoral Fellow at the Delft University of Technology and a National Research Council Postdoctoral Research Fellow at the National Institute of Standards and Technology (Boulder, CO). He leads an independent research group at Penn, focused on nanostructure physics and nanoelectronics. Johnson worked extensively in the science of carbon nanotubes, making significant contributions to the understanding of thermal and electronic transport in this important nanomaterial. More recently he has been active in the area of vapor- and liquid-phase molecular sensing using functionalized nanotube field effect transistors, as well as graphene electronics and synthesis of wafer-scale graphene. Johnson was the recipient of an NSF Graduate Research Fellowship, a Packard Foundation Science and Engineering Fellowship, a Sloan Fellowship, and selection as a Fellow of the American Physical Society, among other honors. Along with the authorship of over 140 peer-reviewed articles, Johnson holds three awarded patents, with 18 other patents submitted. Johnson is a member of the Founding Editorial Board of AIP Advances. He is also a scientific founder of two companies based on technology from his laboratory, Graphene Frontiers and Adamant Technologies.

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LiegnerKenneth B. Liegner, M.D.
Internal & Critical Care Medicine
Lyme Borreliosis & Related Disorders
Pawling, NY

Problems of Lyme Disease Testing

Dr. Kenneth Liegner is a Board Certified Internist with additional training in Pathology and Critical Care Medicine, practicing in Pawling, New York. He has been actively involved in diagnosis and treatment of Lyme disease and related disorders since 1988. He has published articles on Lyme disease in peer-reviewed scientific journals and has presented poster abstracts and talks at national and international conferences on Lyme disease and other tick-borne diseases. He has cared for many persons seriously ill with chronic and neurologic Lyme disease. His work has focused on the serious morbidity and (occasional) mortality that can eventuate from this aspect of the illness. He has emphasized the urgent need for widespread clinical availability of improved methods of diagnostic testing and for development of improved methods of treatment for Lyme disease in all its stages. He holds the first United States patent issued proposing application of acaricide to deer for area-wide control of deer-tick populations as a means of reducing the incidence of Lyme disease.  

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MaloneyElizabeth Maloney, MD
Board certified in Family Medicine
President, Partnership for Health & Healing (accredited CME program provider)
Wyoming, MN

 The Ethics of Clinical Decision-Making When the Scientific Evidence is Unclear or Absent


Elizabeth L. Maloney, MD, is board-certified in family medicine and president of Partnership for Healing and Health, a company providing accredited CME programs on Lyme disease for physicians and other health professionals as well as Lyme disease education and training programs for private organizations and government agencies. She has published on Lyme disease in peer-reviewed journals and frequently lectures on Lyme disease at hospitals and medical conferences.

In addition to her clinical work, Dr. Maloney has held several physician leadership roles. She served as Chief of Staff at District Memorial Hospital and on the Board of Directors of Allina Medical Clinics, a multi-specialty healthcare system. Dr. Maloney is a member of the American Academy of Family Physicians, the Minnesota Academy of Family Physicians and the International Lyme and Associated Diseases Society.

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MiklossybJudith Miklossy, MD, PhD, DSc
Board Certified in Neurology, Psychiatry, Psychotherapy and Neuropathology
Founder, Prevention Alzheimer Foundation
Director, International Alzheimer Research Center
Martigny-Combe, VS Switzerland

 

Late/Chronic Lyme Disease & its Relation to Alzheimer’s Disease

 Dr. Miklossy is the founder of the Prevention Alzheimer International Foundation and director of the International Alzheimer Research Center in Switzerland. She also practices memory and Lyme disease consultation in Vigimed Medical Center, Martigny, Switzerland.

She is board certified in neurology, psychiatry and psychotherapy (Faculty of Medicine, University of Debrecen, Hungary) as well as in neuropathology (Swiss Society of Neuropathology and Swiss Medical Federation). She has received the degrees of Private docent (Dr habil or DSc) and Maître d’Enseignement et de Recherche (MER) in the University Hospital Center of Lausanne (CHUV), University of Lausanne, Switzerland.

She was head of the Neurodegeneration research group for more than ten years in the University Institute of Pathology, Lausanne, Switzerland. She has done molecular biology research and participated in the introduction of Alzheimer’s research in the Center of Neurovirology, Department of Neuroscience, Temple University, Philadelphia, USA. She headed the neuropathology of the Kinsmen Laboratory of Neurological Research, in The University of British Columbia, Vancouver, Canada. She is on the board of directors or scientific advisory board of several international organizations or foundations.

For more than 25 years she is actively involved in research on Alzheimer’s disease and Lyme disease in the framework of international collaborations. Her presentations on international meetings and her publications were repeatedly considered for CME and press releases.

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RheeRichard S. Rhee, M.D., F.A.A.N.
Clinical Professor of neurology
Robert Wood Johnson Medical School, UMDNJ
Founder & President, Jersey Shore Neurology Associates Group
Neptune, NJ

Lyme Disease: Neurologic Differential

Dr. Richard Rhee was born in South Korea and had extensive training in both internal medicine and neurology in New York City including Queens General Hospital (Internal Medicine), New York University – Bellevue Hospital and State University of New York Downstate Medical Center. He is certified in neurology, EEG, EMG and neurosonology. He did a fellowship in neurophysiology at Columbia Presbyterian Medical Center and remained as a part of the teaching faculty from 1971-1975 at the Neurological Institute of Columbia University. He has been in primary practice in neurology as the Founder and President of the Jersey Shore Neurology Associates Group in Neptune, NJ since 1975.

He has served as the President of multiple professional organizations including Monmouth County Medical Society of New Jersey, New Jersey Neurological Society, Korean-American Neurological Association (KANA) (Founding President), President of Korean-American Medical Association (KAMA) and since 1998 he has been serving as a member of the Scientific & Professional Advisory Board, Lyme Disease Association, Inc.

He has published numerous scientific articles in the field of Neurology including Lyme disease and lectured in the U.S.A. and abroad on the topics of neurological Lyme disease.

He has received multiple awards and honors including Prime Minister’s Award by the Republic of Korea, Ellis Island Award by National Ethnic Coalition of Organizations in the U.S.A., Faculty Teaching Award from Robert Wood Johnson Medical School, New Jersey State Board of Medical Examiners and Jersey Shore University Medical Center for his professional contributions. He currently serves as a Clinical Professor of neurology at Robert Wood Johnson Medical School – University of Medicine and Dentistry of New Jersey since 1981.

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ShorSamuel Shor, MD, FACP
Chair, Loudoun County Lyme Commission
Associate Clinical Professor
George Washington University Health Care Sciences
Internal Medicine & HBO Therapy of Northern Virginia
Reston, Virginia

 

Chronic Fatigue Syndrome & Lyme Disease – Is There A Connection?

Samuel Shor, MD, FACP; Associate Clinical Professor, George Washington University Health Care Sciences. Trained in Primary Care Internal Medicine, Dr. Shor has had an interest in chronic fatigue since starting practicing medicine in1985. His first peer reviewed publication was in 2003 on the Pathogenesis of Chronic Fatigue Syndrome a Multisystem Hypothesis. Soon thereafter he became interested in a possible connection between chronic fatigue and Lyme disease. Embracing that topic, he is presently chair of the Loudoun County Lyme commission and was a member of the 2010 Virginia Governor’s Lyme Task Force. He presented on the topic to a congressional hearing in 2008 and has twice been a participant on the nationally syndicated NPR Diane Rehm Show. Dr. Shor will now speak about his peer reviewed original research published in the Spring of 2011 in the on line Bulletin of the International Association of CFS/ME, A Retrospective Analysis of a Cohort of Internationally Case Defined Chronic Fatigue Syndrome Patients in a Lyme Endemic Area, the topic of his talk today.

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StitchR.W. (Bill) Stich, MS, PhD
Professor of Parasitology, Department Veterinary Pathobiology
University of Missouri
Columbia, MO

Persistence of Tick-Borne Infections

Dr. Bill Stich is a Professor of Parasitology in the University of Missouri Department of Veterinary Pathobiology. Bill has worked with a diverse range of metazoan, protozoan and rickettsial parasites that include ticks (Dermacentor, Rhipicephalus, Amblyomma and Ixodes spp.), Schistosoma mansoni, Babesia bovis, Sarcocystis neurona, Neospora caninum, Anaplasma marginale, A. phagocytophilum, Ehrlichia canis and E. chaffeensis. Most of Bill’s work currently involves tick-borne parasites and pathogens, for which he utilizes molecular, proteomic, cellular, immunological and clinical technologies to investigate interactions between these pathogens and their invertebrate and vertebrate hosts.

Bill earned his academic degrees in Veterinary Parasitology at Oklahoma State University, where he studied Anaplasma marginale, a rickettsial pathogen of cattle. These graduate studies included a year of training in the Molecular Biology Division of the Onderstepoort Veterinary Research Institute in South Africa. Bill then studied Schistosoma mansoni, a human ‘blood fluke’, as a postdoctoral research fellow under the auspices of an NIH training grant titled “Molecular and Cell Biology of Parasites and Vectors” at the University of Georgia. Bill then moved to Washington State University to work as a postdoctoral research associate on an NIH grant to investigate innate and adaptive cellular immunity of cattle to Babesia bovis, an important protozoan parasite that causes a highly pathogenic form of bovine babesiosis that is similar to severe human malaria.

After a short time at WSU, Bill joined the faculty of Veterinary Preventive Medicine at The Ohio State University as an assistant professor, where he continued to work on parasitic diseases of livestock caused by intracellular protozoan parasites. It was during this time when Bill began to work with tick-borne pathogens that infect dogs and people. After promotion with tenure at Ohio State, Dr. Stich then transferred to the Department of Veterinary Pathobiology at the University of Missouri as a tenured associate professor, to continue his work on tick-borne rickettsial pathogens in ‘lone star tick country.’ Bill also teaches the nematode and trematode sections of veterinary parasitology while he continues to pursue his long-standing interest in the mitigation of vector-borne diseases of medical and economic importance. These efforts include the control of tick-borne rickettsial diseases through better understanding of the mechanisms underlying transmission and pathogenesis of their etiologic agents. So far Bill has trained seven postdoctoral researchers, five of which were DVM/PhD’s, and he has served as major adviser for five MS and four PhD graduate students. Bill’s work has received support from several grants from the NIH and from industry. Bill also served as President for the Conference of Research Workers in Animal Diseases in 2009, he is a Councilor for the Society for Tropical Veterinary Medicine and on the Board of Directors for the Companion Animal Parasite Council. Bill currently serves on the editorial advisory board of the journal, Veterinary Parasitology, and he is editor in chief of Animal Health Research Reviews. 

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stromdahlEllen Stromdahl, MS, BCE
US Army Public Health Command
Entomological Sciences Program
Aberdeen Proving Ground, MD

US Army Findings in Ticks in the Upper Midwest

Ellen Stromdahl is an entomologist and has worked in the Tick-Borne Disease Program of the U.S. Army Public Health Command (formerly U.S. Army Center for Health Promotion and Preventive Medicine) since 1995.


The Program operates the Tick-Borne Disease Laboratory and produces and disseminates educational materials on tick-borne disease prevention. The Laboratory identifies and tests ticks removed from DOD personnel submitted in the DOD Human Tick Test Kit Program.

Ms. Stromdahl’s research has focused on emerging human pathogens associated with the ticks found in the United States, including Ehrlichia sp. Wisconsin, or “EML”, and other pathogens associated with Ixodes scapularis in the Upper Midwest.

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ViscontiErnest Visconti, MD
Attending in Medicine & Pediatrics
Lutheran Medical Center in Brooklyn;

Pediatric ID at Staten Island University Hospital &
Richmond University Medical Center
Private practice office location
Staten Island, New York

Helpful Hints in the Differential Diagnosis of Lyme Disease

Dr. Ernest Visconti has been attending in medicine and pediatrics at Lutheran Medical Center for 30 years. He also does pediatric ID at Staten Island University Hospital & Richmond University Medical Center. His private practice in infectious disease consists of treating patients with the following diseases: Lyme disease, chronic fatigue, fibromyalgia, Epstein-Barr, other tick-borne diseases, and many other disabilities.

Dr Visconti is also a pediatrician and has a large practice on Staten Island. There he sees well children for their examinations and vaccines. He also sees children with disabilities.

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ZakrisonLeila Zackrison, MD, FACR, FACP
Internal Medicine, Rheumatology
Private Practice Fairfax, VA

Lyme Disease: Rheumatologic/Autoimmune Differential

Leila H Zackrison, MD, FACR, FACP, FAARM, a board certified physician earned her Bachelor of Science, Master of Science and a Doctorate of Medicine from Loma Linda University in California. She did her internship and residency in Internal Medicine and Rheumatology fellowship at Georgetown University Medical Center Washington DC. Dr. Zackrison, (Dr. Z. as she is affectionately called by her patients) is licensed in the Commonwealth of Virginia to practice Medicine and Surgery. She is a Fellow of the American College of Physicians and American College of Rheumatology, and a Fellow of American Academy of Anti-Aging, Regenerative and Functional Medicine. She has been in private practice since 1993 treating patients nationwide using an integrative medicine approach.

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LDA Annual Conf. (June 2013) – Registration

LDA’s 14th Annual Conference

Lyme & Tick-Borne Diseases: Science, Research & Myth

Saturday, June 1 & Sunday June 2, 2013 

University of Minnesota, St. Paul

11.0 Prescribed CME Credits *

 

StPaulStudCtr

 Sponsored by  

  Lyme Disease Association, Inc. 

Co-Chairs

Brian Fallon, MD, Columbia Univ. College of Physicians & Surgeons

RW Stich, PhD, University of Missouri

   


This conference is designed for physicians and researchers.  Other health care professionals and the public are also invited to register.  Adults only.

Online General Registration – [For those who do not require Continuing Medical Education (CME) credits] 

Online CME* Registration  

Printable By Mail Registration Form

Questions on registration contact: treasurer@lymediseaseassociation.org


General Registration Information

►  Fees:
• Regular – $195 (after 5/8/13); $215 (at door – CASH or CHECK only)
• CME – $320 (after 5/8/13); $355 (at door – CASH or CHECK only)

Note: Early registration discount expires on 5/8/13

►  No phone or fax registrations accepted 

►  The availability of last minute “at the door” registrations is determined by the room capacity and number of registrants on day of conference.  Please note, the rate to register “at the door” will be higher than the pre-registration fee.  There is a CASH or CHECK ONLY policy when registering “at the door”. 

►  CANCELLATION: Written notice of cancellation must be received by LDA by 5/8/13 for refund, NO exceptions.  Email cancellation notice to treasurer@LymeDiseaseAssociation.org or fax 732-938-7215

►  AVAILABILITY: Registration subject to space availability at the time of receipt by LDA of completed registration. NO registrations accepted without payment.  


Note : “The University of Minnesota is not endorsing or sponsoring the activities conducted by Lyme Disease Association, Inc. on the University of Minnesota campus. The relationship between the University of Minnesota is solely that of licensor and licensee.”  *Application for CME credit has been filed with the American Academy of Family Physicians

 


 

* This Live activity, Lyme & Other Tick-Borne Diseases: Science, Research & Myth, with a beginning date of 06/01/2013, has been reviewed and is acceptable for up to 11.00 Prescribed credit(s) by the American Academy of Family Physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AMA/AAFP Equivalency:
AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 Credit™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.

 

 




2013 LDA Conference Agenda

11.0 Prescribed CME Credits for Physicians

Saturday Agenda     Sunday Agenda    Conference Information

Lyme & Other Tick-Borne Diseases:  Science, Research & Myth

AGENDA – SATURDAY JUNE 1, 2013

7:15 – 8:00 AM

REGISTRATION/EXHIBITS/CONTINENTAL BREAKFAST

8:00 – 8:10 AM

Patricia V. Smith, President, Lyme Disease Association, Inc.
Welcome & Remarks

8:10 – 8:20 AM

Patricia V. Smith, President, Lyme Disease Association, Inc.
Brief Lyme Overview & Intro of Facilitator: Dr. RW (Bill) Stich

8:20 – 9:00 AM

George Chaconas, PhD    Saturday Keynote Speaker
Live Imaging Studies of Dissemination of the Lyme Spirochete in Mice

Myths

 

9:00 – 9:30 AM

Kenneth Liegner MD
Problems of Lyme Disease Testing

9:30 – 10:00 AM

John Aucott MD
Erythema Migrans (EM) in Lyme Diagnosis

10:00-10:30 AM

Brian A. Fallon, MD, MPH
Lyme Disease or Hypochondriasis

10:30-10:40 AM

MORNING COFFEE BREAK

10:40-11:00 AM

Discussion (Myth panel)

Ticks & TBD’s

 

11:00-11:35 AM

Ellen Stromdahl, MS
US Army Findings in Ticks from the Upper Midwest

11:35-12:10 PM

RW Stich, PhD
Persistence of Tick-Borne Infections

12:10–12:45 PM

Edward Breitschwerdt, DVM
Bartonelliosis: A One Health Approach to a Persisitent Blood-Borne Infection

12:45-1:45 PM

LUNCH BREAK

1:45 PM

Introduction of Session Facilitator:
Elizabeth Maloney, MD

1:45 – 2:00 PM

Discussion (Ticks & Tick-Borne Diseases panel)

Differential Diagnosis

2:00 – 2:35 PM

Richard Rhee, MD
Lyme Disease: Neurologic Differential

2:35 – 3:10 PM

Ernest Visconti, MD
Helpful Hints in the Differential Diagnosis of Lyme Disease

3:10 – 3:25 PM

AFTERNOON COFFEE BREAK

3:25 – 4:00 PM

Leila Zackrison, MD
Lyme Disease: Rheumatologic/Autoimmune Differential

4:00 − 4:35 PM

Sam T. Donta, MD
Issues in the Treatment of Lyme Disease

4:35 − 5:00 PM

Discussion (Afternoon panel)

5:15 – 6:45 PM

NETWORKING RECEPTION

 

 

 

 

 

 

AGENDA – SUNDAY JUNE 2, 2013

7:30 – 8:00 AM

REGISTRATION/EXHIBITS/CONTINENTAL BREAKFAST

8:00 AM

Patricia V. Smith Introduces Session Facilitator:
Brian A. Fallon, MD

8:00 – 8:35 AM

Madeleine Cunningham, PhD
Anti-Neuronal Antibiodies in Lyme Disease

8:35–9:15 AM

Judith Miklossy, MD, PhD, DSc  Sunday Keynote Speaker   Neuropathophysiology of Late/Chronic Lyme Disease & its Relation with Alzheimer’s Disease

9:15–9:50 AM

Nicole Baumgarth, DVM, PhD
B Cell Subversion During Borrelia Infection – A Persistence Strategy?

9:50–10:00 AM

MORNING COFFEE BREAK

10:00–10:35 AM

A.T. Charlie Johnson, PhD
Detecting Lyme Disease Using Antibody-Functionalized Single-Walled Carbon Nanotube Transistors 

10:35–11:10 AM

Sam Shor, MD, FACP
Chronic Fatigue Syndrome & Lyme Disease – Is There A Connection?

11:10-11:45 PM

 

11:45-12:00 N

Elizabeth Maloney, MD
The Ethics of Clinical Decision-Making When the Scientific Evidence is Unclear or Absent

DISCUSSION PANEL

 

 




LDA Lyme Conference: Completed

The Lyme Disease Association,Inc. announces its 14th annual scientific conference, Lyme & Other Tick-Borne Diseases: Science, Research & Myth. The Conference will be held at the University of Minnesota, St. Paul, MN, on Saturday June 1 and Sunday June 2, 2013. 11.0 Prescribed CME Credits are available for Physicians.* Cash or check registration only at the door. 

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Brian A. Fallon, MD, Columbia University College of Physicians & Surgeons and RW (Bill) Stich, PhD, University of Missouri, are conference co-chairs.  Betty Maloney, MD, of Minnesota, also serves on the Planning Committee with the co-chairs.

The conference is designed for physicians and scientists, but the public is invited to register to attend. See the agenda for faculty and topics. Continue to check this website for future registration, additional information about the conference, and exhibitor opportunities. 

University of Minnesota
Continuing Education and Conference Center
1890 Buford Avenue
St. Paul, MN 55108

Click here for directions & Parking Info

Click here for Agenda

Click here for Faculty Biographies
Click here for Conference Flyer


“The University of Minnesota is not endorsing or sponsoring the activities conducted by Lyme Disease Association, Inc. on the University of Minnesota campus. The relationship between the University of Minnesota is solely that of licensor and licensee.” 


* This Live activity, Lyme & Other Tick-Borne Diseases: Science, Research & Myth, with a beginning date of 06/01/2013, has been reviewed and is acceptable for up to 11.00 Prescribed credit(s) by the American Academy of Family Physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AMA/AAFP Equivalency:
AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 Credit™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.

 



Columbia Lyme & TBD Research Center

The Lyme and Tick-Borne Diseases Research Center at Columbia University Medical Center, established in 2007 by the Lyme Disease Association, Inc. and the Lyme Disease Alliance, Inc. (previously Time for Lyme, Inc), continues its focus on conducting research to identify better diagnostics and treatments for patients with chronic symptoms related to Lyme and other tick-borne diseases.

The research and clinical team includes neurologists, psychiatrists, rheumatologists, immunologists, brain imaging analysts, neuropsychologists, and biostatisticians. Current on-going or planned research is focused on further delineating the complex relationship between the immunologic response and the central nervous system in patients with chronic symptoms, testing novel treatment strategies (immune modulatory, brain stimulation, antibiotic), examining the long-term outcome of patients after treatment, identifying biomarkers that may aid in treatment selection, exploring post-mortem specimens from generous donors with well-documented Lyme disease, and collaborating on the development of new diagnostic assays.

In addition, the Center houses a specimen repository from patients with well-characterized Lyme disease and the Center staff educates medical students, residents, and post-residency fellows on the diagnosis and treatment of tick-borne diseases. The Center’s mission is facilitated by the members of its Scientific Advisory Board composed of scientists and clinicians from prominent academic institutions. The Center’s activities are supported by its Advisory Committee and by gifts from donors, private foundations, and state and federal sources. To learn more, go to www.columbia-lyme.org.

2012-ColumbiaTeamSm

 

 

 

 

Columbia Team Members:
Avi Chandra, Charu Sood, Sonya Martin, Roger Hicks,Brian Fallon

 

 

 

 

 

 




Columbia Lyme & Tick-Borne Diseases Research Center

The Lyme and Tick-Borne Diseases Research Center at Columbia University Medical Center, established in 2007 by the Lyme Disease Association, Inc. and the Lyme Disease Alliance, Inc. (previously Time for Lyme, Inc), continues its focus on conducting research to identify better diagnostics and treatments for patients with chronic symptoms related to Lyme and other tick-borne diseases.

The research and clinical team includes neurologists, psychiatrists, rheumatologists, immunologists, brain imaging analysts, neuropsychologists, and biostatisticians. Current on-going or planned research is focused on further delineating the complex relationship between the immunologic response and the central nervous system in patients with chronic symptoms, testing novel treatment strategies (immune modulatory, brain stimulation, antibiotic), examining the long-term outcome of patients after treatment, identifying biomarkers that may aid in treatment selection, exploring post-mortem specimens from generous donors with well-documented Lyme disease, and collaborating on the development of new diagnostic assays.

In addition, the Center houses a specimen repository from patients with well-characterized Lyme disease and the Center staff educates medical students, residents, and post-residency fellows on the diagnosis and treatment of tick-borne diseases. The Center’s mission is facilitated by the members of its Scientific Advisory Board composed of scientists and clinicians from prominent academic institutions. The Center’s activities are supported by its Advisory Committee and by gifts from donors, private foundations, and state and federal sources. To learn more, go to www.columbia-lyme.org.

2012-ColumbiaTeamSm

 

 

 

 

Columbia Team Members:
Avi Chandra, Charu Sood, Sonya Martin, Roger Hicks,Brian Fallon

 

 

 

 

 

 




2012 Conference Speaker Biographies

Click here for pintable pdf

Click on name to link to bio:

Wim C. Ang, MD, PhD Randi Eikeland, PhD Steven J. Norris, PhD
John Aucott, MD Monica E. Embers, PhD Eva Sapi, PhD 
Stephen W. Barthold, DVM, PhD Brian A. Fallon, MD, MPH
Alireza A Shamshirsaz, MD 
Nicole Baumgarth, DVM, PhD Martin Fried, MD Janis J. Weis, Ph.D 
Charles Benjamin Beard, PhD Thomas Greco, MD  
Ibrahim M. Binalsheikh, MD  Linden Hu, MD  Ronald A. Hamlen, PhD
Diego Cadavid, MD
Kim Lewis, PhD Karen Lazarus/Andrea Lefever
Michael Cichon, MD Emmanuel Mongodin, PhD Patricia V. Smith, BA

 


AngWim C. Ang, MD, PhD
Department of Medical Microbiology and Infection Control
VU University Medical Center
P.O. Box 7057
1007 MB, Amsterdam The Netherlands
w.ang@vumc.nl

Serologic tests for Lyme disease – how  reliable are they?

Cornelis Willem (Wim) Ang is associate professor of Medical Microbiology and head of the department of Virology & Serology in the VU University Medical Center Amsterdam, the Netherlands.

After earning his M.D. in 1996 (VU University Medical Center Amsterdam, the Netherlands) he did his PhD (Erasmus University, Rotterdam, The Netherlands) on the pathogenesis of the neuroimmunological disease Guillain-Barré syndrome, with a focus on cross-reactive antibodies. Following his PhD, he trained to become a medical microbiologist. His interests are to develop adequate tools for comparing diagnostic assays, including statistical analysis, and to train microbiologists to bring serological diagnosis of infectious diseases to a higher level. In order to accomplish this, he has initiated a training course in infectious diseases serology for residents in medical microbiology.

He has published more than 50 papers across the discipline of medical microbiology. He is editor-in-chief of the Netherlands Journal of Medical Microbiology and also serves in the Dutch working group for Borrelia diagnosis. Dr Ang is involved in numerous projects on validation and quality aspects of serological diagnosis of infectious diseases.

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AucottJohn Aucott, MD
Instructor in Medicine, Johns Hopkins Hospital
Johns Hopkins University, Baltimore, MD
Private Practice: Board Certified, Internal Medicine
10755 Falls Road, Suite 200
Lutherville, MD, 21093
Office phone: (410) 583-7124
jaucott@jhmi.edu

Early Microbiologic and Immunologic Events in Lyme Disease

Dr. Aucott is a graduate of the University of California at Berkeley where he was elected to the membership of Phi Beta Kappa. He attended the Johns Hopkins University School of Medicine, and is a Diplomate of the American Board of Internal Medicine with sub-specialty training in Infectious Disease and Geographic Medicine at University Hospitals of Cleveland. He served as the Section Head for General Internal Medicine and the Residency Program Director at the Cleveland Veterans Affairs Medical Center while on the faculty at Case Western Reserve University School of Medicine from 1989-1996. He was promoted to Associate Professor of Medicine in 1995.

In 1996, Dr. Aucott returned to Baltimore to join the clinical Faculty of Medicine at Johns Hopkins School of Medicine where his focus has been on clinical translation research in Lyme disease. He is currently the Principal Investigator for the prospective cohort study, SLICE, examining the impact of acute Lyme disease on long-term health outcomes and immune function.

Dr. Aucott is the founder of the Lyme Disease Research Foundation, a public non-profit organization founded to promote research and education in Lyme disease. He has lectured through programs sponsored by Johns Hopkins Divisions of Medicine and Infectious Diseases, the American College of Physicians, and other major medical programs in the United States. He has published numerous articles in the field of infectious diseases and Lyme disease.

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BartholdStephen W. Barthold, DVM, PhD
Department Pathology, Microbiology & Immunology
Center Comparative Medicine/School of Veterinary Medicine
University of California
Davis, CA 95616
swbarthold@ucdavis.edu

Overview of Borrelia burgdorferi in the Mouse: Persistence and Post-Antibiotic Survival?

Stephen W. Barthold, DVM, PhD, Diplomate ACVP, is a Distinguished Professor of Veterinary and Medical Pathology at the University of California Davis, and Director of the UC Davis Center for Comparative Medicine. He received his B.S. and D.V.M. from UC Davis in 1967 and 1969. He served as a Captain in the U.S. Army Veterinary Corps at the U.S. Army Research Institute of Environmental Medicine, Natick, MA from 1969 through 1971, followed by graduate training at the University of Wisconsin, Madison, earning an M.S. and Ph.D. in 1973 and 1974. In 1974, he was appointed Assistant Professor of Comparative Medicine at the Yale School of Medicine, with subsequent promotion to Full Professor in 1989. He went to UC Davis in 1997. Dr. Barthold was elected to the National Academies Institute of Medicine (IOM) in 2001, and is recipient of several career awards, including the AALAS Nathan R. Brewer Award for Career Excellence in Research, UC Alumni Achievement Award, Francis Schofield Medal from the Ontario Veterinary College, Pfizer Research Award, AVMA Charles River Prize, Meriel-AAVMC Excellence in Research Award, and Honorary Diplomate in the ACLAM. His professional specialty is pathology of laboratory rodents and rabbits. He has served on numerous national scientific advisory and review committees, and is past Chairman of the Institute of Laboratory Animal Research (ILAR) Council of the National Research Council. His research has been funded continuously by the NIH for over 35 years, including a primary focus on pathogenesis of Lyme borreliosis for the past 25 years. He has published over 300 peer-reviewed articles, chapters and books.

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BaumgartNicole Baumgarth, DVM, PhD
Center for Comparative Medicine
University of California, Davis
County Rd 98 & Hutchison Dr.
Davis, CA 95616
nbaumgarth@ucdavis.edu

B cell subversion during Borrelia infection – a persistence strategy

Nicole Baumgarth is a DVM, PhD and Professor of Immunology at the Center for Comparative Medicine, University of California, Davis. She is also the Chair of the Graduate Group in Immunology there. Dr. Baumgarth’s research encompasses studies on the regulation of immune responses to infections and B cell biology. Much of her recent work has focused on the regulation of B cell responses and B cell subset responses using mouse models to two very different pathogens and immune responses: Acute influenza virus infection, an infection that fully resolves and induces highly protective and long-lived B cell-mediated immunity, and B cell responses to Borrelia burgdorferi, a bacterial spirochete and the causative agent of Lyme disease. Infections with B. burgdorferi induce strong B cell responses, however, those responses to not result in clearance of the infection. By contrasting a successful with a not-successful B cell response her group hopes to uncover important immune regulatory mechanisms that shape the quality of the B cell response.

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BeardCharles Benjamin (Ben) Beard, PhD
Centers for Disease Control & Prevention
3150 Rampart Road – Mailstop P02
Fort Collins, Colorado 80522

Trends in tick-borne diseases in US

Charles Benjamin (Ben) Beard earned a B.S. in 1980 at Auburn University, a M.S. in 1983 at the Louisiana State University School of Medicine, and a Ph.D. in 1987 at the University of Florida. He served as a post-doctoral fellow and associate research scientist at Yale University School of Medicine from 1987 to 1991. In 1991, he joined the Division of Parasitic Diseases at CDC, where he worked on malaria and Chagas disease, and studied the epidemiology of Pneumocystis pneumonia in persons with AIDS. From 1999 to 2003 he served as Chief of the Vector Genetics Section in the Entomology Branch of the Division of Parasitic Diseases before joining CDC’s Division of Vector-borne Infectious Diseases in Fort Collins, CO, in 2003 where he serves as Chief of the Bacterial Diseases Branch and coordinates CDC’s national programs on Lyme disease, plague, tularemia, and Bartonella. His scientific interests include public health and the biology, ecology, and genetics of insect-borne diseases and vectors. More recently he has been involved coordinating CDC’s work in understanding and mitigating the potential impact of climate variability and change on infectious disease ecology and was recently appointed as the Associate Director for Climate Change in CDC’s National Center for Emerging and Zoonotic Infectious Diseases. He has published over 100 scientific papers, books, and book chapters collectively, and has served on a variety of committees and panels both inside and outside of CDC. He is currently an Associate Editor for Emerging Infectious Diseases and past president of the Society for Vector Ecology.

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Binalsheikh-2Ibrahim M. Binalsheikh, MD
Tufts University Dept. of Pediatric Neurology
Floating Hosp. for Children 800 Washington St. Box 330
Boston, MA 02111
alsheikh55@yahoo.com

Neurologic Lyme disease and Alice in Wonderland syndrome

Following a MD degree in medicine 2000 from Dammam University, Saudi Arabia, I finished 4 years of pediatric residency in the National Guard hospital, Riyadh. I started pediatric neurology residency 2008 in the Floating Hospital for Children at TMC, Boston. Currently I am attending Dr. Eric Frank lab at the Sackler School, Tufts University, Boston. My current research is to study the specificity of sensory nerve regeneration in the spinal cord using H reflex recording. I published:

1.Binalsheikh I, Griesemer D, Wang S, Alvarez-Altalef R. Lyme neuroborreliosis presenting as alice in wonderland syndrome. Pediatr Neurol. 2012 Mar;46 (3):185-6.

2.Binalsheikh I, Wang S “Anti N-methyl-D-aspartate (NMDA) Receptor Limbic Encephalitis presenting as refractory seizure followed by Hashimoto’s thyroiditis and systemic lupus erythematosus : Case Report and Review. Poster presentation.

Child Neurology Soc., 40th annual meeting, Savannah, GA, 2011.

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CadavidDiego Cadavid MD
Biogen Idec
14 Cambridge Center
Cambridge, Massachusetts 02142
diego.cadavid@biogenidec.com

Blood brain barrier & impact of Borrelial infection

Dr. Cadavid received his undergraduate and graduate degree in Medicine and Surgery from Pontificia Universidad Javeriana in Bogotá, Colombia, his post-doctoral training in microbiology and immunology from the University of Texas Health Science Center in San Antonio, Texas, his residency training in clinical neurology from Georgetown University in Washington, DC, and his fellowship in Neuropathology from the Armed Forces Institute of Pathology also in Washington, DC.

After completing his medical education, Dr. Cadavid joined the faculty of UMDNJ-New Jersey Medical School and over a ten-year period worked in clinical practice and basic and clinical research in the field of multiple sclerosis and neuro-inflammation. He was the principal investigator of the BECOME study, the first head to head randomized clinical trial comparing the efficacy by MRI analysis of glatiramer acetate (Copaxone) and interferon beta-1b (Betaferon) for treatment of multiple sclerosis. He has been principal investigator of two NIH and one American Heart Association grants to study inflammatory injury to the blood brain barrier during borrelial infection. He left UMDNJ as Associate Professor in the Tenure track in 2008 to join the Biogen Idec MS Clinical Development Group.

He is currently the Medical Director of the anti LINGO-1 clinical development program that targets CNS repair via remyelination and neuroaxonal protection. He is investigating the efficacy of VLA-4 blockade with natalizumab for treatment of the ambulatory and cognitive impairments of secondary progressive multiple sclerosis. Dr. Cadavid has published over 70 peer-reviewed publications and book chapters on the subjects of CNS infections, multiple sclerosis, and brain pathology. He is a member of the American Academy of Neurology, the American Neurological Association, and the American Society of Microbiology. He is currently Consultant at the Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital in Boston. He is also Adjunct Associate Professor of Neurology and Neuroscience at UMDNJ-New Jersey Medical School.

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CichonMichael Cichon, MD
9804 N. 56th St.
Tampa, FL 33617
mcichon@tampabay.rr.com

Considerations in the diagnosis and treatment of tick-borne diseases

Dr. Michael Cichon is an Internist in Tampa area for the last 37 years. He is Board Certified in Internal medicine and Infectious diseases. He is a member of the Infectious Disease Society of America and International Lyme Association or the ILADS as well as a Fellow of the American College of Physicians. He received his Bachelors of Science at the University of Illinois and Masters in Public Health and Environmental Sciences at the University of Oklahoma. His medical degree is from the Chicago Medical School in 1972. He completed his residence and fellowship at the University of South Florida in Tampa.

He has always maintained a practice of internal medicine and complimented with infectious diseases. He has been involved with the chronic fatigue syndrome and fibromyalgia aliments since its onset and the last 12 years a growing involvement with Lyme Disease and its co-infections has come to the forefront; realizing along the way that probably the cause of chronic fatigue and fibromyalgia is Lyme and its co-infections. Over time, various therapies have evolved based on his large practice and treating Lyme disease and the co-infections.

Dr. Cichon has maintained an affiliation with the University of South Florida throughout his career as a consulting attendant both in Internal Medicine and Infectious Disease in the past and now is a clinical associate professor with medical students rotating through his office. He has a wealth of knowledge and experience as a practicing physician.

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EikelandRandi Eikeland, PhD
Arendal Hospital Department of Neurology
Sørlandet Hospital
Arendal, Norway
randi.eikeland@sshf.no

Long-term follow up study of neurologic Lyme disease

Current position:
Senior consultant Department of neurology and researcher, Department of Neurology, Sørlandet Hospital, Norway
PhD “long term follow up after neuroborreliosis” 2012
Education: MD (1993) RWTH Aachen, Germany
Specialist in Neurology, Norway: 2002
PhD, University of Bergen, Norway: 2012
Others: 2005-2002 Member of the Norwegian Committee of specialization in neurology.

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EmbersMonica E. Embers, PhD
National Primate Research center Bldg. B, Room 206
18703 Three Rivers Rd. Covington, LA 70433
members@tulane.edu

Post-treatment persistence and sero diagnosis of Lyme disease: studies in rhesus macaques

I received a Bachelor’s of Science degree in 1996 from McPherson College, majoring in Biology and Chemistry. As an undergraduate, I completed two Howard Hughes Medical Institute-sponsored summer research fellowships. In 2003, I received a Ph.D. in Microbiology and Immunology from The Pennsylvania State University College of Medicine. Post-doctoral studies were performed at Penn State and later at the Tulane National Primate Research center.

I am currently a Research Assistant Professor in the Division of Bacteriology and Parasitology at the Tulane National Primate Research Center. My research studies to date have examined immunity and pathogenesis as they relate to both viral and bacterial infections. While my doctoral research focused on immune responses to a viral infection, my current research examines immune evasion strategies of persistent infection by the Lyme disease agent, Borrelia burgdorferi. My experience in microbiology and immunology has involved primate models of bacterial infection including Borrelia burgdorferi, Borrelia turicatae and Moraxella species. Specifically, I have experience with the measurement of immune responses and the detection of organisms in tissues of infected animals. I also have 15 years of experience with rodent models of infection and immunity.

My research program regarding Borrelia burgdorferi and Lyme disease is designed around three foci: (1) antibiotic efficacy against Lyme disease; (2) intradermal immunity and vaccination against infection; and (3) immunodiagnosis for B. burgdorferi infection and cure. The first research goal is to examine the efficacy of antibiotic treatment during disseminated B. burgdorferi infection using xenodiagnosis in the nonhuman primate model of Lyme disease. The second focus is to gain understanding of the skin cell responses by the host to tick saliva and B. burgdorferi during tick feeding, a process that inhibits both wound-healing and inflammation. An adjunct to this work is the use of route-appropriate (intradermal) vaccination against this vector-borne disease to determine the effectiveness of priming the immune response in skin. A third interest is in the development of a quantitative multi-antigen test that expands detection limits and helps to distinguish persistent infection from clinical cure. In addition, I am working with collaborators to develop a primate model of relapsing fever borreliosis.

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Fallon2Brian A. Fallon, MD, MPH (Course Co-Director)
Professor of Psychiatry
Director, Lyme and Tick-Borne Diseases Research Center,
Columbia University Medical Center
Director, Center for the Study of Neuroinflammatory Disorders & Biobehavioral Medicine, New York State Psychiatric Institute
1051 Riverside Drive, Unit 69
New York, NY 10032

Phone: 212-534-6510 for Dr. Fallon & Avi Chandra
Consultations: 212-543-6508
baf1@columbia.edu

Lyme Disease, Depression, and Suicide

Brian A. Fallon, MD, MPH. Dr. Fallon is director of the Lyme & Tick-borne Diseases Research Center at Columbia University Medical Center where he leads a team focused on biomarkers, diagnostics and treatment of chronic Lyme symptoms. His team’s recent work has included the testing of novel diagnostic assays in a large community study, with the net result of the identification of a more sensitive Lyme Western blot. His team’s work on Lyme encephalopathy led to the discovery of hundreds of unique proteins present in the CSF of Lyme patients but not in the CSF of patients with chronic fatigue syndrome or healthy controls. His team’s current focus is on clarifying the immunologic profile and neural circuitry of patients with persistent symptoms. His team is also investigating the CNS metabolic effects of intravenous ceftriaxone using MR Spectroscopy to probe glutamatergic transmission. Dr. Dwork in his Center is examining the neuropathologic findings in post-mortem studies of patients with chronic Lyme symptoms. Dr. Moeller in his Center is examining the interaction between peripheral immunologic markers, central immune markers, and brain neurocircuitry among patients with chronic symptoms with the goal of identifying of biomarkers to help guide treatment recommendations.

Dr. Fallon serves on the editorial and review board of three journals, has lectured and published widely, and most recently has led an international team for the American Psychiatric Association’s revision of DSM-5 to clarify the prevalence of illness anxiety in the general population.

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Fried3Martin Fried, MD
3200 Sunset Ave, Suite 100
Ocean, New Jersey 07712
www.healthydays.info
Phone 732-682-3425 / Fax 732-455-3309
martinfried@optonline.net

Nutrition & Lyme disease

Dr Martin Fried, is a pediatric gastroenterologist, a board certified Pediatrician and a Board Certified Physician Nutrition Specialist. He is the founder and former Director of the division of Pediatrics Gastroenterology and Nutrition at Jersey Shore University Medical Center. In the 13 years of practice at Jersey Shore University Medical Center, Dr Fried published 5 original research articles on Lyme disease and coinfections. He has presented his research at numerous Lyme conferences and Pediatric Gastroenterology conferences from 1993 to present. He is a graduate of Upstate Medical University in Syracuse. He did a Pediatric Nutrition Fellowship Training program in Toronto Canada (1989-1991), and was a fellow in Pediatric Gastroenterology and Nutrition at Columbia Presbyterian Medical Center, Babies Hospital in 1991-1992. He is private practice in Ocean New Jersey.

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GrecoThomas Greco, MD
St Mary’s Hospital
133 Scovill St. – Suite 306 Waterbury, CT 6706
tgreco@stmh.org

Antiphospholipid antibodies in patients with purported chronic Lyme disease

Dr. Thomas Greco graduated from Georgetown University cum laude and earned his medical degree from Georgetown University School of Medicine. He completed his internship and residency in internal medicine, and fellowship in rheumatology, infectious disease, and allergy and immunology at Yale School of Medicine. He is board certified in internal medicine and rheumatology. He has been at Saint Mary’s Hospital n Waterbury, Connecticut for 35 years and serves as Chief, Section of Inflammatory diseases. An Associate Clinical Professor of medicine at Yale, he teaches residents and medical students at Saint Mary’s Hospital and continues to do clinical research on many illnesses related to aPL.

He has published numerous articles on topics which include testing for the antiphospholipid antibodies in the antiphospholipid syndrome, along with their associations in various disease processes including coronary artery disease, multiple sclerosis, muscle disorders, skin disorders, and most recently Lyme disease among other illnesses.

Dr. Greco has spent the past twenty years researching and treating many patients who have antiphospholipid antibodies – noting, “these blood factors may provide answers for many patients with undiagnosed symptoms and illnesses.”

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HuLinden Hu, MD
Tufts Medical Center
Division of Geomed/ID, Box 41
800 Washington St. Boston, MA 02111
lhu@tuftsmedicalcenter.org

Reservoir targeted vaccines for control of Lyme disease

Dr. Linden Hu is Professor of Medicine at Tufts University School of Medicine and Vice Chairman for Faculty Development in the Dept. of Medicine at Tufts Medical Center. He received his A.B. in Human Biology and M.D. from Brown University. He did his residency in Internal Medicine at St. Elizabeth’s Medical Center in Boston and a fellowship in Infectious Diseases at Tufts Medical Center.

Dr. Hu is involved in both clinical and laboratory based research into Lyme disease. His focus is on the mechanisms by which the spirochete adapts to its various natural hosts and evades the host immune responses. His laboratory is also developing reservoir-targeted vaccines to reduce transmission of tick borne diseases in the wild.

Dr. Hu has been a member or Chairman of numerous peer review committees for the NIH and the National Research Fund for Tick-borne Diseases. He has received a Daland Fellowship from the American Philosophical Society and the Maxwell Finland Award from the Massachusetts Infectious Disease Society and is a Fellow of the Infectious Disease Society of America. In 2010, he was elected to the American Society for Clinical Investigation. Dr. Hu teaches at Tufts Medical School and at the Sackler School of Graduate Biomedical Studies where he is training faculty in the Programs in Microbiology and in Immunology.

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LewisKim Lewis
Northeastern University
306C Mugar Life Sciences
360 Huntington Avenue Boston, MA 02115
k.lewis@neu.edu

Antibiotic tolerance & microbial persistence

Kim Lewis is a University Distinguished Professor and Director, Antimicrobial Discovery Center at Northeastern University in Boston, and a Fellow of the American Society of Microbiology.

He obtained his Ph.D. in Biochemistry from Moscow University in 1980, and has been on the Faculty of MIT, University of Maryland, and Tufts University prior to coming to Northeastern.

Dr. Lewis has authored over 100 papers and is an inventor on several patents. His more notable findings include the discovery of synergistically-acting antimicrobials in medicinal plants [1,2]; a general method to grow previously “unculturable” bacteria that make up >99% of biodiversity on the planet [3,4], the invention of sterile surface materials [5]; the development of high-throughput screening for antimicrobials in a live infected animal (C. elegans) [6]; and the discovery of the culprit of recalcitrant biofilm infections, drug-tolerant persister cells [7,8,9,10,11].

Dr. Lewis presented over 80 invited lectures. Dr. Lewis has been a permanent member of the Drug Discovery and Drug Resistance NIH Study Section, and Chair of two NIH Study Sections on Drug Discovery. Dr. Lewis has served as a panelist and contributor to the National Academies Institute of Medicine reports on antibiotic resistance in 2010 and 2011. Dr. Lewis is a member of Faculty 1000, a world-wide panel of experts evaluating research advancements. He is a recipient of the MIT C.E. Reed Faculty Initiative Award for an innovative research project (1992), and is a recipient of the NIH Director’s Transformative Award (2009).

Dr. Lewis has been funded by the NSF, DOE, NIH, ARO, and the Bill and Melinda Gates Foundation. Apart from his work in Academia, Dr. Lewis has served as a consultant to the Pharmaceutical Industry, The Biotech, and is a founder of two Biotech Companies, NovoBiotic Pharmaceuticals, and Arietis Corporation and serves as a member of the Scientific Advisory Board of Seres.

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MongodinEmmanuel Mongodin, PhD
Institute for Genome Sciences
University of Maryland BioPark II
801 West Baltimore Street, Office #622 Baltimore, MD 21201
emongodin@som.umaryland.edu

Genome stability of Lyme disease spirochetes

Originally trained as a physiologist, I am a microbiologist with a kin interest in research focused on the application of microbial genomics and comparative genomics approaches to the study of host-pathogen interactions, as well as the microbial populations colonizing the human body. During my Ph.D. work at the university of Reims-Champagne-Ardenne (France), I investigated the adherence mechanisms of Staphylococcus aureus to human respiratory epithelial cells. The results of my doctoral research project shed light into the mechanisms involved into the adherence of opportunistic bacterial pathogens, such as S. aureus but also Pseudomonas aeruginosa, to the human respiratory tract, as well as the bacterial virulence factors involved in the invasion and colonization of the human airways.

Following my doctoral work, I started my postdoctoral training in the laboratory of Dr. Gordon Archer (Chair, Infectious Diseases Department, VCU, Richmond, VA), one the world’s leading expert in the S. aureus and S. epidermidis research. In his lab, I researched the mechanisms of acquisition of antibiotic resistance by these two organisms. S. aureus is the most common cause of hospital- and community-acquired infections, and can cause a range of illnesses from minor skin infections to life-threatening diseases, such as pneumonia, endocarditis, toxic shock syndrome and septicemia. S. aureus has become resistant to the most commonly used antibiotics, rendering any antibiotic treatment following an infection by this organism completely ineffective. During my post-doctoral training I became a visiting scientist at The Institute for Genomic Research (TIGR, Rockville, Maryland) and collaborated with Dr. Steven Gill on the sequencing, annotation and analysis of the genomes of S. aureus strain COL and S. epidermidis strain RP62A (Gill et al. 2005). The work on these two genomes allowed me to acquire the knowledge base of microbial genome sequencing, which I then applied to various microbial genome-sequencing projects after I became a staff scientist first at TIGR and later at the J. Craig Venter Institute. Most importantly, this work on the COL and RP62A genomes laid the foundation for post-genomic functional characterization on these two organisms. In collaboration with Dr. Gill, I developed microarray tools to explore the transcriptional profiles of these bacteria during the acquisition of antibiotic (oxacillin and vancomycin) resistance in Staphylococci.

Following my postdoctoral training with Dr Archer, I became a Staff Scientist in Dr. Karen Nelson’s lab at The Institute for Genomic Research, now the J. Craig Venter Institute (JCVI). At JCVI, I played a major role in the management of various microbial genome-sequencing projects, such as Arthrobacter aurescens (a soil bacterium that can consume and break down environmental pollutants), Salinibacter ruber (the only known bacterium that thrives in environments with very high concentrations of salt), various strains of Campylobacter species (a major cause of human bacterial gastroenteritis), outbreak strains of Listeria monocytogenes (bacteria associated with food-borne illness outbreaks), as well as 17 strain representatives of the major Borrelia species causing Lyme disease: Borrelia burgdorferi, Borrelia afzelii, Borrelia garinii and Borrelia valaisiana.

In 2007, I joined as an Assistant Professor the Department of Microbiology and Immunology at the University of Maryland School of Medicine (SOM) and the Institute for Genome Sciences (IGS), where I focused my research on the human microbiome using metagenomic approaches. In complex environments where most species are not cultivable, characterization of the microbial species present and of the functions they perform can be achieved through metagenomics approaches, without the need for isolation and lab cultivation of individual species. Some of the metagenomic projects I am currently involved in are focused on the microbial communities inhabiting the human gut, and the impact they have on diseases such as obesity and Crohn’s disease. Other projects include the characterization of the microbial communities inhabiting the oral cavity of healthy subjects and in subjects with periodontal and endodontic diseases, and the microbiome associated with S. aureus colonization in the anterior nares.

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NorrisSteven J. Norris, PhD
University of Texas-Houston Medical School
6431 Fannin Street, MSB 2.120 Houston, Texas 77030
Steven.J.Norris@uth.tmc.edu

How do Lyme disease Borrelia cause disease?

Steven J. Norris, Ph.D. received a bachelor’s degree in Psychobiology at UCLA, then gradually evolved toward microbiology while obtaining an M.S. in Biochemistry and Molecular Biology at UC Santa Barbara, a Ph.D. in Microbiology and Immunology at UCLA in 1980, and postdoctoral training at UC San Diego. Most of his career has focused on understanding host-pathogen interactions of invasive bacteria. Dr. Norris began his faculty career at the University of Texas Medical School at Houston in 1982 and continued studies on the physiology and in vitro culture of Treponema pallidum, the spirochete that causes syphilis. His work expanded into molecular genetics with participation in the sequencing and annotation of the T. pallidum and T. denticola genomes. Studies on the pathogenesis of Borrelia burgdorferi, the Lyme disease agent, resulted in the discovery and characterization of the vls locus (an elaborate antigenic variation system) in 1996. In 2007, Dr. Norris received the University of Texas Chancellor’s Entrepreneurship and Innovation Award for the development of a new immunodiagnostic test for Lyme disease using the protein VlsE. Recent work has focused on the implementation of genetic approaches for the identification of additional virulence determinants and important immunogens in Lyme disease and syphilis spirochetes. His group is currently screening a transposon insertion library in B. burgdorferi in an attempt to identify every gene important in Lyme disease pathogenesis. With Dr. Jun Liu and other collaborators, Dr. Norris is also examining spirochetal structure using cryoelectron tomography and additional techniques.

Dr. Norris is a Fellow of the American Academy of Microbiology, and has served as the chair of the American Society for Microbiology Division of General Medical Microbiology and of the Gordon Research Conference on the Biology of Spirochetes. Leadership roles in the UT Health Science Center at Houston include President of the Faculty of the Graduate School of Biomedical Sciences, Chair of the Faculty Senate of the Medical School, and Chair of the Curriculum Committees for both the Graduate School and the Medical School. Service to the scientific community is exemplified by regular membership on NIH grant review panels and editorial board positions for the journals Infection and Immunity and Molecular Microbiology. Dr. Norris also received the Faculty Mentor of the Year in 2000 for his role in fostering the development of faculty in the Medical School. He is currently the Robert Greer Professor in Biomedical Sciences and Vice Chair of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. A more detailed description of Dr. Norris’ research and links to recent references can be found at http://www.uth.tmc.edu/pathology/faculty/faculty-norris-steven.html.

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Sapi2Eva Sapi, PhD
Associate Professor and University Research Scholar
Director of the Lyme Disease Research Program
Department of Biology and Environmental Science
University of New Haven
300 Boston Post Road GH 104A
West Haven, CT 06510
Phone: (203) 479-4552
esapi@newhaven.edu

In Vitro antimicrobial sensitivity studies

Dr. Sapi received her PhD degree in Genetics from the University of Eotvos Lorand (Budapest Hungary). She had her postdoctoral training at Yale University where she studied the effects of different hormonal factors on the development of breast and ovarian cancer. She currently is an Associate Professor at the University of New Haven where she teaches graduate biology courses and carries out Lyme disease research with her graduate students. Her research team was established 8 years ago and to date, over 60 graduate students have received training in Lyme disease related research.

In the last several years UNH Lyme disease research group has identified an alarming increase in the co-infection rate in deer ticks, including discovery of novel co-infections such as mycoplasma and microfilarial nematode species. In the last 3 years the Lyme research group has received several extramural grant supports from the Turn the Corner Foundation, Lyme Disease Association and Californian Lyme Disease Association which will allow the group to investigate novel ideas for Lyme disease research.

Recently her research group studies the different forms of Borrelia burgdorferi bacteria to better understand how Borrelia can hide from the immune system and from different therapies. With collaboration with Dr. Alan MacDonald, the research group discovered that Borrelia burgdorferi is capable forming a protective layer around itself – called biofilm – which could render it to be very resistant to antibiotics and provide a logical explanation as to why extensive antibiotic treatment for patients with a tick-bite history could fail. The goal of her research group is to identify novel antibacterial agents that are effective in killing all forms (spirochete, round bodies and biofilm) of Borrelia burgdorferi.

Dr. Sapi organized and chaired four National Lyme Disease Symposiums at the University of New Haven during the last several years (2006-2011).

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ShamshirsazAlireza Abdollah Shamshirsaz, MD
Department of Obstetrics and Gynecology University of Connecticut Health Center 263 Farmington Avenue
Farmington , CT
alirezashamshirsaz@yahoo.com

Tick-borne diseases and pregnancy

Alireza Abdollah Shamshirsaz, MD from the Department of Obstetrics and Gynecology at the University of Connecticut Health Center
Medical Licensure:
2010-Present: State License, Connecticut #049189.
Jun 2009: Passed Written Examination of “American Board of Obstetrics and Gynecology”, Active candidate
Mar 2005: Educational Commission for Foreign Medical Graduates (ECFMG) Certified
August 2001: Permanent Medical License, Iran.
Peer Reviewer:
Journal of Gynecologic Oncology
Ultrasound in Obstetrics and Gynecology
American Journal of Kidney disease
British journal of Haematology
Journal of Medicine and Medical Sciences
Iranian Journal of Pediatrics
OMICS Publishing group
Current Projects:
Early prediction of fetal complications in monochorionic diamniotic twin pregnancies with ultrasound examination.
Periventricular leukomalacia and placental histopathologic abnormalities.
Maternal weight gain in twin pregnancies and its outcomes.
Fetal echocardiography in the Greater Hartford area 2001-2010; indications, outcome and influence of nuchal translucency.
Improving fetal Down syndrome risk assessment using the first trimester combined test and second trimester sonography.
Genital Mycoplasmas and Neonates outcomes.

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WeisJanis J. Weis, PhD
Professor of Pathology
University of Utah
15 North Medical Drive #2100
Salt Lake City, UT 84112-5650
janis.weis@path.utah.edu

Mouse model of chronic inflammatory response to B. burgdorferi

Janis J. Weis, Ph.D., is Professor of Pathology, Division of Microbiology and Immunology at the University of Utah School of Medicine in Salt Lake City. Dr. Weis received the Ph.D. in Microbiology from the University of Minnesota, followed by post-doctoral training in Immunology at Brigham and Women’s Hospital/Harvard Medical School. She was selected as a Biomedical Scholar of the Lucille P. Markey Charitable Trust in 1985. Dr. Weis became an Assistant Professor in the Department of Pathology at the University of Utah in 1988, attaining the rank of Full Professor in 1999. Dr. Weis maintains an active research laboratory at the University of Utah studying the mechanism and genetic regulation of Lyme arthritis development. She is also actively involved in graduate student education and serves as director of the Training Program in Microbial Pathogenesis, an NIH sponsored training grant that supports pre-doctoral and postdoctoral trainees in this discipline. Dr. Weis has served on numerous grant review panels and advisory boards including the Board of Scientific Counselors for the National Institutes of Allergy and Infectious Diseases, Study Sections of the National Institutes of Health, the Centers for Disease Control, the Howard Hughes Medical Institution Research Training Fellowships committee, the Arthritis Foundation Inflammation Study Section, the National Research Fund for Tick-Borne Diseases, the Lyme Center Scientific Advisory Board, the Gordon Research Conference Council. Dr. Weis has maintained an active research program in the host-pathogen interactions associated with Borrelia burgdorferi infection and the pathogenesis of Lyme arthritis. This work has been supported by the National Institutes of Health since 1993. Her current studies are focused on understanding the inflammatory dysregulation associated with acute and chronic Lyme arthritis in mice. Recent studies have identified in B. burgdorferi-infected IL-10 deficient mice several key features that are similar to features seen in patients with Post Treatment Lyme Disease Syndrome. This suggests that the IL-10 deficient mouse may provide a model to study the sustained inflammatory response to B. burgdorferi and gain insight into its underlying cause.

Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Gerald J. Spangrude GJ, Zachary JF, Weis JH, Weis JJ. Localized Production of IL-10 Suppresses Early Inflammatory Cell Infiltration and Subsequent Development of IFN-g-Mediated Lyme Arthritis, 2012. J Immunol 188: 1381-1393.

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HamlenRonald A. Hamlen, PhD
9 Locharron Drive
Elkton, Maryland
rhamlen@comcast.net

Poster Presentation: Prevention of Tick-Borne Infections: A focus on school-aged children.

Ron Hamlen received a PhD in Plant Pathology and Nematology and postdoctoral training in Insect Pathology and Microbial Insect Control from the Pennsylvania State University. Dr. Hamlen also received a certificate in Health Risk Assessment from the Harvard School of Public Health. Dr. Hamlen is currently Vice President and Science Advisor for the Lyme Disease Association of Southeastern Pennsylvania, and a member of the International Lyme and Associated Diseases Society, and he has served as a member of the Delaware Task Force to Examine the Prevalence of Lyme Disease in Delaware. Formerly a Biology Research Fellow and Global Technical Product Manager for E. I. DuPont de Nemours and Co., Inc. and an Associate Professor of Entomology and Nematology with the University of Florida. Dr. Hamlen, now retired, conducts public, corporate, and state government seminars on Lyme disease and related tick-borne infections. Dr. Hamlen has published research and review articles on Lyme disease, related tick-borne infections & their prevention.

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Karen Lazarus (Saturday) klazarus@chesco.org
Andrea Lefever (Sunday) alefever@chesco.org
West Chester Co.DOH 601 Westtown Rd. West Chester, PA 19380

 

Poster Presentation: The Localized Prevalence and Impact of Lyme Disease in Chester County, PA

Karen Lazarus is a Master’s candidate from Drexel University School of Public Health concentrating in environmental & occupational health. She has spent this past summer researching the prevalence and impact of Lyme disease with the Chester Co. Health Dept. She received her Bachelor’s from Temple in 2010 in communications and urban planning and hopes to continue researching human interactions with the built and natural environments.

Andrea LeFever, Public Health Educator, Chronic Disease and Injury Prevention Division, Chester County (PA) Health Dept. works in numerous public health program areas such as Lyme disease, tobacco education, cardiovascular disease, & nutrition. She holds a Master’s Degree in Public Health – Community Health and Bachelor’s Degree in Business Management from West Chester University, PA

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Patricia V. Smith
President, Lyme Disease Association, Inc. (LDA)
PO Box 1438 Jackson, NJ 08527
President@LymeDiseaseAssociation.org

Conference Organizer

Patricia V. Smith, a Monmouth University graduate, has entered her 16th year as President of the all-volunteer national non-profit Lyme Disease Association. A member of Columbia University’s Lyme & Tick-Borne Diseases Research Center Advisory Committee, member of the Food & Drug Administration’s (FDA) PESP Partnership to promote avoidance of tick exposure, and Advisor to Lyme Research Alliance, CT, she is also former Chair of the (NJ) Governor’s Lyme Disease Advisory Council, former President/12-year member of the Wall NJ Board of Education and was FDA’s 2011 Lyme prevention conference session co-chair with CDC. In 2011 she presented a Lyme session to the New Jersey Education Association’s Annual Meeting. Ms. Smith, a 27+ year Lyme advocate, has raised funds for researchers nationally─research acknowledged in 25 scientific journals.

Besides speaking, publishing, TV/radio appearances and organizing 13 CME accredited Lyme scientific conferences for doctors, she’s testified for and secured passage of state and federal bills for Lyme research and physician’s right to treat. Working with author Amy Tan, she created LDA’s LymeAid 4 Kids, a fund for children with no health coverage for Lyme.

Chosen Jackson NJ’s Chamber of Commerce 2008 Woman of the Year, she has also received a certificate of Special Congressional Recognition from RI Congressman James Langevin, and had a flag flown over the US Capitol by request of NJ Congressman Christopher Smith in honor of her work on Lyme. In 2012, she was an invited to testify before the Foreign Affairs Committee, Africa, Global Health & Human Rights Subcommittee in Washington, DC.

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Stephen W. Barthold, DVM, PhD

 

Barthold

Stephen W. Barthold, DVM, PhD
Dept. Path., Microbio. & Immunology
Centr. Comparative Medicine/Sch Vet Med.
University of California
Davis, CA 95616
swbarthold@ucdavis.edu

 

 

Overview of Bb in the mouse – persistence & antibiotic response

Stephen W. Barthold, DVM, PhD, Diplomate ACVP, is a Distinguished Professor of Veterinary and Medical Pathology at the University of California Davis, and Director of the UC Davis Center for Comparative Medicine. He received his B.S. and D.V.M. from UC Davis in 1967 and 1969. He served as a Captain in the U.S. Army Veterinary Corps at the U.S. Army Research Institute of Environmental Medicine, Natick, MA from 1969 through 1971, followed by graduate training at the University of Wisconsin, Madison, earning an M.S. and Ph.D. in 1973 and 1974. In 1974, he was appointed Assistant Professor of Comparative Medicine at the Yale School of Medicine, with subsequent promotion to Full Professor in 1989. He went to UC Davis in 1997. Dr. Barthold was elected to the National Academies Institute of Medicine (IOM) in 2001, and is recipient of several career awards, including the AALAS Nathan R. Brewer Award for Career Excellence in Research, UC Alumni Achievement Award, Francis Schofield Medal from the Ontario Veterinary College, Pfizer Research Award, AVMA Charles River Prize, Meriel-AAVMC Excellence in Research Award, and Honorary Diplomate in the ACLAM. His professional specialty is pathology of laboratory rodents and rabbits. He has served on numerous national scientific advisory and review committees, and is past Chairman of the Institute of Laboratory Animal Research (ILAR) Council of the National Research Council. His research has been funded continuously by the NIH for over 35 years, including a primary focus on pathogenesis of Lyme borreliosis for the past 25 years. He has published over 300 peer-reviewed articles, chapters and books.




Brian A. Fallon, MD, MPH

Dr. Fallon is director of the Lyme & Tick-borne Diseases Research Center at Columbia University Medical Center where he leads a team focused on biomarkers, diagnostics and treatment of chronic Lyme symptoms.  His team’s recent work has included the testing of novel diagnostic assays in a large community study, with the net result of the identification of a more sensitive Lyme Western blot.  His team’s work on Lyme encephalopathy led to the discovery of hundreds of unique proteins present in the CSF of Lyme patients but not in the CSF of patients with chronic fatigue syndrome or healthy controls.   His team’s current focus is on clarifying the immunologic profile and neural circuitry of patients with persistent symptoms.  His team is also investigating the CNS metabolic effects of intravenous ceftriaxone using MR Spectroscopy to probe glutamatergic transmission.   Dr. Dwork in his Center is examining the neuropathologic findings in post-mortem studies of patients with chronic Lyme symptoms.  Dr. Moeller in his Center is examining the interaction between peripheral immunologic markers, central immune markers, and brain neurocircuitry among patients with chronic symptoms with the goal of identifying of biomarkers to help guide treatment recommendations.   Dr. Fallon serves on the editorial and review board of three journals, has lectured and published widely, and most recently has led an international team for the American Psychiatric Association’s revision of DSM-5 to clarify the prevalence of illness anxiety in the general population.