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Luchini, Alessandra

Alessandra Luchini, PhD luchini
Associate Professor, Applied Proteomics & Molecular Medicine
George Mason University, VA

“Nanotechnology and Proteomics: Improved Diagnostics and Therapeutics in the Era of Personalized Medicine”

Alessandra Luchini is Associate Professor at George Mason University. Her research interests are focused on developing technologies that improve current diagnostics and therapeutics for devastating diseases including cancer, inflammatory and infectious diseases. Dr. Luchini authored peer reviewed publications in scientific journals in chemistry, nanotechnology and proteomics and is co-inventor in a series of issued and licensed patents covering her Mason nanotechnology research.

Dr Luchini is co-founder of Ceres Nanosciences Inc. that was created in 2008. In 2009, Dr. Luchini was awarded the Premio award for the top Italian scientist working in the US, Canada and Mexico and the Euwiin Gold Innovation in Science award. In 2011 Dr. Luchini was named as one of the top 10 most brilliant scientists by Popular Science. Dr. Luchini earned a degree in Chemical Engineering cum laude and a PhD in Bioengineering both at the University of Padova, Padova, Italy.


Conference Lecture Summary

Nanotrap Urinary Lyme Antigen Test – I will talk about the progress on conquering Lyme disease is severely hindered by the poor quality of existing diagnostic tests for Lyme. Patients with a missed diagnosis harbor Lyme that persists to invade brain, heart, joints, and other tissues. We also need a test to monitor if the disease is successfully treated.

Our Laboratory is dedicated to the development of a highly specific and sensitive urine antigen test for Lyme disease that can be used for diagnosis or monitoring therapy. We created a special nanotechnology, called the Nanotrap, that enables us to increase the sensitivity of our test one thousand times higher than previous testing methods. We are testing for regions of the Lyme surface proteins that are absolutely specific for the Lyme bacteria and detect all species and strains. We are also developing a tick panel test for other tick borne bacteria and viruses that infect patients. We have published our first clinical study and are we are now using our test in a nationwide clinical study.




Fallon, Brian

Brian A. Fallon, MD, MPH (Conference Director)
Professor of Psychiatry
Director, Lyme and Tick-Borne Diseases Research Center
Columbia University Medical Center
Director, Center for the Study of Neuroinflammatory Disorders & Biobehavioral Medicine, New York State Psychiatric Institute
New York, NY
baf1@columbia.edu
Lyme and Tick-Borne Diseases Research Center

“Acute & Chronic Neuropsychiatric Lyme Disease”

Brian A. Fallon, MD, MPH. Dr. Fallon is director of the Lyme & Tick-borne Diseases Research Center at Columbia University Medical Center where he leads a team focused on biomarkers, diagnostics and treatment of chronic Lyme symptoms. His team’s recent work has included the testing of novel diagnostic assays in a large community study, with the net result of the identification of a more sensitive Lyme Western blot. His team’s work on Lyme encephalopathy led to the discovery of hundreds of unique proteins present in the CSF of Lyme patients but not in the CSF of patients with chronic fatigue syndrome or healthy controls. His team’s current focus is on clarifying the immunologic profile and neural circuitry of patients with persistent symptoms. His team is also investigating the CNS metabolic effects of intravenous ceftriaxone using MR Spectroscopy to probe glutamatergic transmission. Dr. Dwork in his Center is examining the neuropathologic findings in post-mortem studies of patients with chronic Lyme symptoms. Dr. Moeller in his Center is examining the interaction between peripheral immunologic markers, central immune markers, and brain neurocircuitry among patients with chronic symptoms with the goal of identifying of biomarkers to help guide treatment recommendations.

Dr. Fallon serves on the editorial and review board of three journals, has lectured and published widely, and most recently has led an international team for the American Psychiatric Association’s revision of DSM-5 to clarify the prevalence of illness anxiety in the general population.


Conference Lecture Summary

Dr. Fallon will review the acute and chronic neuropsychiatric manifestations of Lyme disease. Mechanisms of disease, neuroimaging and neurocognitive findings, and treatment approaches will be discussed. New findings from a sample of 200 patients with prior Bb infection will be presented.




Esvelt, Kevin

esvelt2Kevin Esvelt, PhD
Leader, Sculpting Evolution Group
Assistant Professor, MIT Media Lab
Massachusetts Institute of Technology, Cambridge, MA

“Community-Guided Ecological Immunization to Prevent Tick-Borne Disease”

Kevin Esvelt is an assistant professor of MIT and leader of the Sculpting Evolution group at the MIT Media Lab, which specializes in developing tools to reshape populations and ecosystems. An evolutionary engineer, Esvelt received his Ph.D. from Harvard University in 2010 for inventing a synthetic microbial ecosystem for rapidly evolving useful biomolecules. As a Technology Development Fellow of the Wyss Institute, he helped pioneer the development of a powerful new method of genome engineering based on CRISPR/Cas9, an enzymatic scalpel that can be programmed to cut DNA at any desired sequence.

In 2014, Esvelt and his team were the first to outline how CRISPR could be used to build evolutionarily stable “gene drives” capable of altering wild populations of sexually reproducing organisms. Recognizing the potential implications of a unilateral method of reshaping shared ecosystems, he and his colleagues detailed ways to control, block, or even reverse changes made by gene drives while emphasizing the importance of laboratory safeguards to ensure they do not accidentally escape the laboratory. To set an example for future research in this field, they chose to reveal their findings before experimenting with CRISPR gene drives in the laboratory so that public notification and discussion could guide research and safeguards.

There is little precedent for deciding whether, when, and how to use “collective” technologies whose deployment can affect entire communities. In addition to exploring ecological and evolutionary engineering, Esvelt seeks to establish a new model of open and responsive science in which revealed community expectations guide the development of powerful technologies with shared impacts.


Conference Lecture Summary

The island communities of Nantucket and Martha’s Vineyard are guiding a project to prevent Lyme and other tick-borne diseases by heritably immunizing local populations of wild white-footed mice. Past studies have shown that immunizing mice can substantially reduce the number of infected ticks, which are the source of human infections. We are now sequencing vaccinated mice to identify the antibodies they have evolved to acquire resistance. We will test these mouse antibodies to find the ones that are most protective, then encode them in the genome to create mice that are immune from birth. Releasing these mice on the islands in reasonable numbers over multiple generations would stably introduce the trait to a large fraction of the native mouse population. Island citizens, which were invited to direct the project before any experiments were performed, will make all key decisions and ultimately determine whether the project moves forwards at each stage. If successful, mainland communities could choose to gain the same benefits by using daisy drive systems to spread the antibodies through their own local mouse populations. Precisely blocking disease transmission at its source may be the smallest possible intervention capable of permanently preventing tick-borne disease.

www.sculptingevolution.org

 




Coyle, Patricia

CoylePatricia K. Coyle, MD, FAAN, FANA
Professor & Vice Chair (Clinical Affairs) Department of Neurology
Director, MS Comprehensive Care Center
Stony Brook University Medical Center
Stony Brook, New York

“Diagnosing Neurologic Lyme Disease”

Patricia K. Coyle, MD, FAAN, FANA, is Professor and Vice Chair (Clinical Affairs) of Neurology, and Director of the Multiple Sclerosis Comprehensive Care Center at Stony Brook University Medical Center, Stony Brook, New York. She received a BS degree with highest honors from Fordham University, Bronx, New York, and an MD degree from the Johns Hopkins School of Medicine, where she was elected to Alpha Omega Alpha. While at the Johns Hopkins School of Medicine, she completed a residency and chief residency in neurology, followed by a two-year fellowship in neurovirology and neuroimmunology. She then went on to establish a successful research laboratory in addition to building a busy clinical practice at the Stony Brook University Medical Center.

Dr. Coyle is the author of numerous articles on clinical and basic research aspects of neurologic infections and multiple sclerosis (MS). She is recognized as a leading expert in the areas of Lyme disease and neurologic infections, cerebrospinal fluid, therapeutics, and neuroimmunology. Her research has been supported by the National Institutes of Health and other organizations, and she directed a Program Project grant on Neurologic Lyme disease. She is currently involved in studies addressing neurologic aspects of Lyme disease, and therapeutic trials testing new immunotherapies for MS. In addition to her busy clinical and research careers, she has held active leadership positions in a number of national and international organizations and academic societies, including the American Academy of Neurology, American Neurological Association, National MS Society, and the American Board of Psychiatry and Neurology. She served on the FDA CNS/PNS Advisory Panel and currently serves on the Southampton Hospital Tick Resource Center Advisory Panel. She lectures widely on neurologic infections and MS to national and international audiences.


Conference Lecture Summary

Lyme disease is our major human spirochetal infection. The nervous system is a favored target organ. This talk will discuss the diagnosis of neurologic Lyme disease in practical terms. It will cover when to suspect the infection, characteristic as well as unusual syndromes, the main differential diagnoses, and appropriate workup including how to interpret the variety of test results. The goal is not to miss the diagnosis of neurologic Lyme disease, so that appropriate and timely treatment may be provided.




Cameron, Daniel

CameronDaniel Cameron, MD, MPH
Internist, Epidemiologist
Dr. Daniel Cameron & Associates
Mt. Kisco, NY

“Lyme Disease Clinical Trials, Past, Present & Future”

Dr. Daniel Cameron graduated with degrees in Medicine and Epidemiology from the University of Minnesota followed by residencies at both Beth Israel Medical Center and Mt. Sinai School of Medicine in New York City.

Dr. Cameron is past president of ILADS, the International Lyme and Associated Diseases Society. He has led the field of clinical epidemiology in Lyme disease as an author of the 2004 and 2014 ILADS evidence based treatment guidelines and analytic reviews. He has been treating patients with Lyme disease in his private practice in Mt. Kisco, New York. He regularly communicates by Blog and Facebook at www.DanielCameronMD.com.


Conference Lecture Summary

Lyme disease trials continue to frustrate doctors. Short-term successes following treatment for early Lyme disease were followed by reports of chronic manifestations including chronic neurologic Lyme disease, Lyme encephalopathy, Post Treatment Lyme disease and neuropsychiatric Lyme disease. Retreatment trial outcomes have been mixed following early reports of successful treatment for Chronic Neurologic Lyme, Lyme Encephalopathy and Post Lyme Disease. Watchful waiting outcomes trials are similarly mixed. 14.47 % of 76 subjects in one watchful waiting study suffered from Post Treatment Lyme Disease Syndrome (PTLDS) at either six or twelve months despite a one time 3-week course of doxycycline. Eleven percent of individuals in another watchful waiting study suffered from PTLDS for more than 11 years despite timely treatment. Future trial designs will need to adapt to our growing understanding of the complexity of tick borne illnesses.




Beard, Ben

BeardC. Ben Beard, MS, PhD
Chief, Bacterial Diseases Branch
Division of Vector-Borne Diseases
Associate Director for Climate and Health
National Center for Emerging & Zoonotic Infectious Diseases, CDC, Ft. Collins, CO

“The Expansion in Distribution of Ixodes scapularis & Ixodes pacificus and Reported Cases of Lyme Disease in the U.S.”

Charles Benjamin (Ben) Beard earned a B.S. in 1980 at Auburn University, a M.S. in 1983 at the Louisiana State University School of Medicine, and a Ph.D. in 1987 at the University of Florida. He was a post-doctoral fellow and associate research scientist at the Yale University School of Medicine from 1987 to 1991. In 1991, he joined CDC’s Division of Parasitic Diseases, where he served as Chief of the Vector Genetics Section from 1999 to 2003. In 2003 he moved to CDC’s Division of Vector-borne Diseases in Fort Collins, CO to become Chief of the Bacterial Diseases Branch. In this capacity, he coordinates CDC’s programs on Lyme disease, tick-borne relapsing fever, Bartonella, plague, and tularemia. During his 25-year tenure at CDC, Ben has worked in the prevention of vector-borne diseases, both in the domestic global arenas. In addition to his work as Chief of the Bacterial Diseases Branch, in 2011 Dr. Beard was appointed as the Associate Director for Climate Change in CDC’s National Center for Emerging and Zoonotic Infectious Diseases, where he coordinates CDC’s efforts to mitigate the potential impact of climate variability and disruption on infectious diseases in humans. In his efforts to coordinate activities and enhance communication across the U.S. government in the prevention of Lyme disease, Dr. Beard co-founded and co-moderates two informal federal working groups on Lyme and other tick-borne diseases. The first is the HHS Lyme and Tick-Borne Diseases Working Group and the second is the federal Tick-Borne Diseases Integrated Pest Management Working Group. He has published over 100 scientific papers, books, and book chapters collectively, and has served on a variety of committees and panels both inside and outside of CDC, including working groups or advisory panels for the World Health Organization, the Bill & Melinda Gates Foundation, and the American Meteorological Society. He is currently an Associate Editor for Emerging Infectious Diseases and past president of the Society for Vector Ecology.


Conference Lecture Summary

Ixodes scapularis or Ixodes pacificus are now found in over 49% of counties in 43 states across the United States. This marks an increase of 44.7% in the number of positive counties since 1996. The number of counties where I. scapularis is now established has more than doubled over the last 20 years. Over a similar period of time, the number of high incidence counties for Lyme disease in the northeastern U.S. increased by greater than 320% and in the north-central U.S. by over 250%. The numbers of Lyme disease cases in the U.S. continue to increase, and the geographic distribution of both Lyme disease and its tick vectors is greater than ever before. These findings highlight the critical importance of safe and effective prevention and control tools and methods.

 




Maloney, Elizabeth

MaloneyElizabeth L. Maloney, MD
President, Partnership for Tick-Borne Diseases
Family Practice Physician
Wyoming, MN

“Lyme Carditis: A Front-Line Perspective”

Dr. Elizabeth L. Maloney is a family physician from Minnesota. She received her undergraduate degree from the College of St. Catherine in 1980 and her medical degree from the University of Minnesota Medical School in 1986. She also completed her residency training at the University of Minnesota in 1989.

Dr. Maloney has more than 25 years of experience in Family Medicine and she has held several different physician-leadership positions during her career. Her current focus is on tick-borne diseases education and policy and she is the founder and president of Partnership for Tick-borne Diseases Education, a 501(c)(3) organization providing educational programs and materials on tick-borne diseases for medical professionals and the general public.

Much of Dr. Maloney’s work is focused on the development of accredited continuing medical education courses primary care physicians. Beginning in 2007, she provides accredited evidence-based continuing medical education courses for physicians and other healthcare professionals. She currently hosts a free, accredited online course at lymecme.info. Dr. Maloney frequently speaks at medical conferences and hospitals across the US. She has authored or co-authored several papers on Lyme disease, including the International Lyme and Associated Diseases Society’s 2014 treatment guidelines – Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease.

Dr. Maloney also serves as a consultant to government agencies and private organizations. In May of this year, Health Canada (the Canadian Health Ministry) invited her to participate in their conference to reframe Canada’s Lyme disease guidelines. She’s trained Army Corps of Engineers and Boy Scout staffs on tick bite prevention. Dr. Maloney enjoys educating the public regarding the scientific evidence of tick-borne diseases. In addition to her many speaking engagements, she provides evidence-based online resources at


Conference Lecture Summary

This presentation begins with a case presentation before moving to a broader discussion of Lyme carditis. It traces the evolution of the patient’s clinical picture from multiple erythema migrans lesions to third degree heart block. In addition to reviewing the literature on Lyme carditis, the presentation highlights some unique features of the case-patient’s course that may inform the care of other patients.

www.partnershipfortickbornediseases.org




Columbia Lyme & Tick-Borne Diseases Research Center

The Lyme and Tick-Borne Diseases Research Center at Columbia University Medical Center, established in 2007 by the Lyme Disease Association, Inc. and the Lyme Disease Alliance, Inc. (previously Time for Lyme, Inc), continues its focus on conducting research to identify better diagnostics and treatments for patients with chronic symptoms related to Lyme and other tick-borne diseases.

The research and clinical team includes neurologists, psychiatrists, rheumatologists, immunologists, brain imaging analysts, neuropsychologists, and biostatisticians. Current on-going or planned research is focused on further delineating the complex relationship between the immunologic response and the central nervous system in patients with chronic symptoms, testing novel treatment strategies (immune modulatory, brain stimulation, antibiotic), examining the long-term outcome of patients after treatment, identifying biomarkers that may aid in treatment selection, exploring post-mortem specimens from generous donors with well-documented Lyme disease, and collaborating on the development of new diagnostic assays.

In addition, the Center houses a specimen repository from patients with well-characterized Lyme disease and the Center staff educates medical students, residents, and post-residency fellows on the diagnosis and treatment of tick-borne diseases. The Center’s mission is facilitated by the members of its Scientific Advisory Board composed of scientists and clinicians from prominent academic institutions. The Center’s activities are supported by its Advisory Committee and by gifts from donors, private foundations, and state and federal sources. To learn more, go to www.columbia-lyme.org.

2012-ColumbiaTeamSm

Columbia Team Members:
Avi Chandra, Charu Sood, Sonya Martin, Roger Hicks,Brian Fallon




Organizing Committee, Planner, & Staff 2016

Lyme & Other Tick-Borne Diseases: New Strategies to Tackle an Expanding Epidemic

The individuals listed below planned, organized, and carried out conference preparation to ensure the conference meets the needs of the accreditation agency and of the attendees.

Conference Organizing Committee

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Brian A. Fallon MD, MPH
Professor of Clinical Psychiatry
Director, Lyme & Tick-Borne Diseases Research Center
Center for Study of Neuroinflammatory Disorders & Biobehavioral Medicine

Columbia University College of Physicians & Surgeons
New York, New York

(Conference Director, Conference Organizing Committee)

 Maloney

 

Elizabeth L. Maloney, MD
President, Partnership for Tick-Borne Diseases Education,
a Lyme CME Provider
Wyoming, Minnesota

(Conference Organizing Committee)

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Patricia V. Smith, BA
President, Lyme Disease Association, Inc. (LDA)

Jackson, New Jersey

(Conference Organizing Committee, Conference Planner)

  

LDA All Volunteer Staff 

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Pamela Lampe
LDA Board of Directors
Executive Vice President & Treasurer

Lyme Disease Association, Inc.
Jackson, New Jersey

alt

 

Corey W. Lakin, BS
LDA Board of Directors
2nd Vice President, Technical Support

Lyme Disease Association, Inc.
Jackson, New Jersey

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Ruth Waddington, RN
LDA Board of Directors
Corresponding Secretary

Lyme Disease Association, Inc.
Jackson, New Jersey

Richard Smith  

Richard H. Smith, BA
LDA Board of Directors Member

Lyme Disease Association, Inc.
Jackson, New Jersey

timlynagh2

 

Tim S. Lynagh, MBA
LDA Board of Directors Member

Lyme Disease Association, Inc.
Jackson, New Jersey




2016 Conference Hotel Information

doubletree stpaulLDA/Columbia CME Lyme Conference

Lyme & Other Tick-Borne Diseases:
New Strategies to Tackle an Expanding Epidemic

October 15 -16, 2016

Doubletree by Hilton St. Paul Downtown, 411 Minnesota Street, St. Paul, Minnesota 55101, USA


HOTEL RESERVATIONS FOR LDA ROOM BLOCK (until September 15, 2016, or until full) 

Online Reservations:

Click here for online reservation Room Block or call 651-291-8800 (direct to hotel)

At the time of reservation, you must tell the hotel the code “Lyme Disease Association Annual Conference” for the room block discount


FACTS ABOUT LDA ROOM BLOCK HOTEL RESERVATIONS

Cut off date for room block discount is September 15, 2016 or when the block is full, whichever is earlier.

Rate is only guaranteed if you reserve using the LDA code (“Lyme Disease Association Annual Conference”).

Special room requests may be indicated but cannot be guaranteed.

Check-in Thursday Oct. 13 at 3:00pm / Check-out Sunday Oct. 16 at 11:00am

Rates below do not include tax.

Single Occupancy: $139
Double Occupancy: $139

TRANSPORTATION

Directions:
General Hotel Info / Directions

Nearest Airport:
Minneapolis-Saint Paul International Airport (MSP / KMSP)

Closest Bus Station:
Greyhound

Closest Train Station:
St. Paul Amtrak Station