Valneva and Pfizer announced that they have initiated a Phase 2 study for their Lyme disease vaccine candidate. This new study builds on previous studies, including new dose regimens as well as being the first clinical study to include children between the ages 5-17 years.
Lyme disease is a bacterial disease which in the US is caused by the bacteria Borrelia burgdorferi or newly discovered Borrelia mayonii. The bacteria can attack all of the systems in the body and produce many different Lyme disease symptoms, which is why it has often been called the great imitator. Women with Lyme disease who are pregnant or are thinking of becoming pregnant need to receive appropriate care from a knowledgeable Lyme disease doctor. Information on Lyme and pregnancy can be found in this section. Guidelines which help doctors with Lyme treatment have been developed and some can be found here, as well as various photos and videos pertaining to Lyme disease bacteria.
A peer-reviewed report co-authored by Melissa C Fesler and Raphael B Stricker has been published in the International Journal of General Medicine which evaluates pre-exposure prophylaxis (PrEP) using medications approved for use in pregnant women to prevent gestational problems and severe illness in this high-risk population.
According to “TrialSite News” on January 21, “Apparently, a judge just ordered the Millard Fillmore Suburban Hospital to allow an 80-year old woman to be treated with Ivermectin. A New York Supreme Court judge ordered hospital to allow her to be treated with Ivermectin for COVID-19. Ivermectin, which had been administered in the ICU with […]
In a retrospective review on the use of Disulfiram as a repurposed drug in the treatment of Lyme and Babesiosis, most patients experienced benefits with regard to their symptoms. It was found that although patients on high dose experienced higher risk for adverse reactions than the low dose patients, they were also more likely to […]
A new direct test for Lyme disease was announced by Galaxy Diagnostics Inc., the Nanotrap® Urine Test for Lyme Borreliosis. This is a urine-based Lyme antigen test, that Galaxy states “provides the most sensitive direct detection of Borrelia burgdorferi infection at all stages of the disease.” The test is easily administered through collection of urine; and identifies positive cases […]
Richard Horwitz, MD, et al., have published a new case study and retrospective chart review of 40 patients on double dose dapsone combination therapy (DDD CT) in the journal Antibiotics.
The study found that of the 40 patients analyzed, an 8-week course of dapsone combined with doxycycline and rifampin effectively improved symptoms in 98% of patients, as well as led to long-term remission in 45% of the total patients studied, even though most of the individuals were ill for a decade or longer.
New in vitro study on dapsone (diaminodiphenyl sulfone), and dapsone combination therapy (DDS CT) was just published by Dr. Richard Horowitz et al. and provides hope of effective treatment for patients with persistent Lyme disease. The study is suggestive that dapsone combination therapy may well characterize both a novel and successful option to treat Borrelia […]
West Virginia University researchers received a $1.9 million grant from the National Institute of Allergy and Infectious Diseases, an institution of the National Institute of Health (NIH), for a vaccine to prevent humans from contracting Lyme disease. Mariette Barbier, assistant professor in the School of Medicine’s Department of Microbiology, Immunology and Cell Biology, is leading […]
With a new $3.5 million grant from the National Institutes of Health (NIH), Utpal Pal, PhD, professor in Veterinary Medicine at the University of Maryland (UMD) will be partnering with Matthias Schnell, director of the Jefferson Vaccine Center at Thomas Jefferson University to develop a novel “next-generation” Lyme disease vaccine. Pal, a tick immunobiologist, and […]
Clinical practice treatment guidelines are often used as reference by physicians for Lyme disease treatment and treatment of other tick-borne diseases. The LDA provides some links here for informational purposes only, as LDA does not make specific treatment recommendations. The only Lyme disease treatment guidelines that that were posted on the National Guidelines Clearinghouse (NGC), […]